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CABOZANTINIB
SynDRA canonical compound SYN0031584 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | TEK |
|---|
| Mechanism of action | RET tyrosine kinase inhibitor |
|---|
| Indication | medullary thyroid cancer (MTC) |
|---|
| Disease area | oncology |
|---|
All known targets
- KDR
- MET
- RET
- TEK
- FLT3
- KIT
- SRC
- RIPK3
- RIPK2
- PTK6
- PIP4K2C
- NTRK1
Mechanisms of action (all sources)
- VEGFR inhibitor
- RET tyrosine kinase inhibitor
- KDR INHIBITOR
- Vascular endothelial growth factor receptor 2 inhibitor
- MET INHIBITOR
- Hepatocyte growth factor receptor inhibitor
- RET INHIBITOR
- KIT INHIBITOR
- FLT3 INHIBITOR
- TEK INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CHRM1
- HTR2B
- MERTK
- KCNH2
- ERBB2
- TBXA2R
- SLTM
- DRD1
- HTR2A
- ADORA3
- ADRA1A
- PDE4D
- TYRO3
- ABCB11
- SYK
- CHRM2
- YES1
- PAK6
- PAK4
- AAK1
- PAK2
- PDE3A
- OPRM1
- OPRD1
- OPA1
- OLA1
- NUAK2
- NR3C1
- NR1I2
- NQO2
- PAICS
- PDGFRA
- PDE4A
- NEK9
- PPARG
- PLK4
- PLK1
- PKN2
- PKN1
- PKMYT1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CCDC6
- CP2C9
- CP3A7
- IFNB1
- IFNG
- KIF5B
- KSYK
- NSD2
- TP53
Drug classes
- Protein Kinase Inhibitors
- Kinase Inhibitor
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- CABOMETYX
- COMETRIQ
- Cabometyx
- Cometriq
- cabozantinib malate
- cabozantinib (S)-malate
- cometriq
- XL184
- cabozantinib S-malate
- cabometyx
- BMS-907351
- BMS-907351 FREE BASE
- CABOZANTINIB (BMS-907351)
- Cabozantinib s-malate
- CABOZANTINIBCT-XL184COMETRIQXL184C3627
- XL-184
- XL-184 FREE BASE
- XL184 FREE BASE
- XL184,BMS-907351
- XL 184
- BMS 907351
- XL-184 free base
- Cabozantinib (XL184, BMS-907351)
- Cabozantinib [USAN]
- CHEBI:72317
- BMS907351
- 1C39JW444G
- MFCD20926324
- Cabozantinib (USAN)
- XL-184 (Cabozantinib,BMS907351)
- Cabometyx (TN)
- Cometriq (TN)
- XL184 cpd
- Cabozantinib [USAN:INN]
- Carbozantinib
- UNII-1C39JW444G
- XL184 free base
- Cabozantinib (free base)
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