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TELOTRISTAT ETHYL
SynDRA canonical compound SYN0031563 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | TPH1 |
|---|
| Mechanism of action | tryptophan hydroxylase inhibitor |
|---|
| Indication | diarrhea |
|---|
| Disease area | gastroenterology |
|---|
All known targets
Mechanisms of action (all sources)
- TPH2 INHIBITOR
- Tryptophan 5-hydroxylase inhibitor
- TPH1 INHIBITOR
- tryptophan hydroxylase inhibitor
- Serotonin release inhibitor
- Serotonin receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA3
- PDE4D
- CCKAR
- ADORA1
- NR3C1
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- NR1I2
- OPRK1
- OPRD1
- HRH2
- OPRM1
- PDE3A
- PGR
- PPARG
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- HRH3
- HRH1
- ADORA2A
- CCKBR
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- CP2C9
- CP3A7
- GAMT
- GNMT
- HLAB
- HNMT
- IFNB1
- IFNG
- KSYK
- NNMT
- NSD2
- PNMT
- SYK
ATC classes
- A16A · OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Cross-references
Synonyms
- XERMELO
- Xermelo
- xermelo
- telotristat etiprate
- LX1606
- LX 1606
- LX-1032
- LX-1606
- LX1032
- Telotristat
- Telotristat etiprate
- LP-778902
- Serotonin modulator (oral, GI disorder/hypertension/carcinoid syndrome), Lexicon
- Tryptophan hydroxylase inhibitor (oral, GI disorder/hypertension/carcinoid syndrome), Lexicon
- telotristat.ethyl
- Telotristat ethyl [USAN]
- 8G388563M7
- Telotristat ethyl (USAN)
- LX-1606 Hippurate
- Telotristat Etiprate (LX 1606 Hippurate)
- UNII-8G388563M7
- Xermelo (TN)
- SCHEMBL610588
- TELOTRISTAT ETHYL [MI]
- GTPL9490
- CHEMBL2105695
- EX-A322
- BDBM445704
- DTXSID001102271
- TELOTRISTAT ETHYL [WHO-DD]
- AMY38688
- HY-13055A
- LX1606LX1606
- MFCD18251583
- ZINC43205655
- BCP9000866
- DB12095
- US10683309, Example LX1606
Reported adverse events
- Depression
- Flatulence
- Headache
- Decreased appetite
- Nausea
- Pyrexia
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