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VORTIOXETINE
SynDRA canonical compound SYN0030957 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A4
- HTR1A
- HTR3A
- HTR7
- HTR1B
- HTR5A
- HTR1D
- HTR6
- HTR2C
- HTR2A
- Slc6a3
- Htr7
Mechanisms of action (all sources)
- Serotonin receptor agonist
- Serotonin receptor antagonist
- HTR1A AGONIST
- Serotonin 1a (5-HT1a) receptor agonist
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- HTR3A ANTAGONIST
- Serotonin 3a (5-HT3a) receptor antagonist
- HTR1A PARTIAL AGONIST
- HTR1B PARTIAL AGONIST
- HTR3A PARTIAL AGONIST
- HTR3B PARTIAL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP2D6
- CYP3A4
- PTGS1
- PTGS2
- CYP1A2
- CYP2A6
- CYP2C9
- CYP2E1
- FMO3
- HDAC6
- KCNH2
- MC4R
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1B
- 5HT2A
- 5HT5A
- 5HT6R
- 5HT7R
- KSYK
- NSD2
- SYK
Drug classes
- Anti-Anxiety Agents
- Antidepressive Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Selective Serotonin Reuptake Inhibitors
- Serotonin 5-HT1 Receptor Agonists
- Serotonin 5-HT3 Receptor Antagonists
- Serotonin Agents
ATC classes
Cross-references
Synonyms
- TRINTELLIX
- Trintellix
- vortioxetine DL-lactate
- brintellix
- Lu AA21004
- vortioxetine hydrobromide
- Vortioxetina
- LU-AA21004
- LUAA21004
- Brintellix
- Lu-AA21004
- UNII-3O2K1S3WQV
- 3O2K1S3WQV
- CHEBI:76016
- Brintellix (TN)
- CHEMBL2204360
- LuAA21004
- vortioxetina
- vortioxetinum
- RefChem:57757
- N06AX26
- DTXCID801392739
- Vortioxetine free base
- Vortioxetine [USAN]
- C18H22N2S
- Vortioxetine (USAN)
- Vortioxetine [USAN:INN]
- VTX
- MFCD22380814
- PS37 - Vortioxetine
- Vortioxetine (Standard)
- VORTIOXETINE [MI]
- VORTIOXETINE [INN]
- VORTIOXETINE [VANDF]
- Vortioxetine, Lu AA21004
- SCHEMBL236115
- VORTIOXETINE [WHO-DD]
- GTPL7351
Reported adverse events
- Abnormal dreams
- Constipation
- Dizziness
- Nausea
- Pruritus
- Sexual dysfunction
- Vomiting
- Dry mouth
- Flatulence
- Hypersensitivity
- Hypomania
- Mania
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