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TRAMETINIB
SynDRA canonical compound SYN0030073 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | MAP2K2 |
|---|
| Mechanism of action | MEK inhibitor |
|---|
| Indication | melanoma |
|---|
| Disease area | oncology |
|---|
All known targets
- MAP2K1
- MAP2K2
- ABCB1
- CYP2C8
- CYP3A4
Mechanisms of action (all sources)
- MEK inhibitor
- MAP2K2 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
- MAP2K1 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
- Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- BRD4
- AAK1
- PDGFRA
- PIM1
- PHKG2
- PGRMC1
- PFKP
- PEBP1
- PDXK
- PDK1
- PDGFRB
- PCYT1A
- NTRK2
- PASK
- PAK6
- PAK4
- PAK2
- PAICS
- OPA1
- OLA1
- OGG1
- PIM2
- PIP4K2A
- PIP4K2C
- PRKACG
- PRKCG
- PRKCE
- PRKCD
- PRKCB
- PRKCA
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACB
- PKMYT1
- PRKACA
- PRKAA1
- PLK4
- PLK3
- PLK1
Drug classes
- Protein Kinase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Kinase Inhibitor
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- MEKINIST
- Mekinist
- TRAMETINIB DIMETHYL SULFOXIDE
- GSK1120212B
- trametinib dimethyl sulfoxide
- GSK1120212
- mekinist
- TMT212
- CPD 8B
- GSK-1120212
- JTP-74057
- TMT-212
- TRAMETINIB (GSK1120212)
- Trametinib dimethyl sulfoxide
- Trametinib (GSK1120212)
- Trametinib (GSK1120212JTP 74057)
- Trametinib (MEK inhibitor)
- 33E86K87QN
- A1-01871
- AK174783
- CHEBI:75998
- UNII-33E86K87QN
- GSK 1120212
- GSK212
- Trametinib [USAN]
- Trametinib (USAN)
- Trametinib [USAN:INN]
- trametinibum
- JTP74057
- QOM
- TRAMETINIB [MI]
- TRAMETINIB [INN]
- TRAMETINIB [VANDF]
- TRAMETINIB [WHO-DD]
- SCHEMBL170938
- GTPL6495
- GSK1120212 (Trametinib)
- CHEMBL2103875
Reported adverse events
- Abdominal pain
- Acne
- Alopecia
- Anxiety
- Arthralgia
- Atrioventricular block
- Atrioventricular block complete
- Bradycardia
- Cardiomyopathy
- Chills
- Colitis
- Constipation
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