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LUMACAFTOR
SynDRA canonical compound SYN0030068 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CFTR |
|---|
| Mechanism of action | CFTR channel agonist |
|---|
| Indication | cystic fibrosis |
|---|
| Disease area | pulmonary |
|---|
All known targets
Mechanisms of action (all sources)
- CFTR STABILISER
- Cystic fibrosis transmembrane conductance regulator stabiliser
- CFTR BINDER
- CFTR channel agonist
- CFTR REGULATOR
- CFTR PHARMACOLOGICAL CHAPERONE
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ADORA1
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- NR1H4
- NR3C1
- HRH1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PPARG
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- HRH2
- HDAC6
- ADORA2A
- CCKBR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CP3A7
- GPX4
- MITF
- SNCA
- SYUA
- TFE3
- TP53
Drug classes
- P-Glycoprotein Inhibitors
- Cytochrome P450 2C9 Inhibitors
- Cytochrome P450 2C9 Inducers
- Cytochrome P450 2C19 Inducers
- Cytochrome P450 2C8 Inhibitors
- Cytochrome P450 2C8 Inducers
- Cytochrome P450 2B6 Inducers
- Cytochrome P450 3A Inducers
- P-Glycoprotein Inducers
ATC classes
- OTHER RESPIRATORY SYSTEM PRODUCTS
Cross-references
Synonyms
- ORKAMBI
- VX-809
- VRT-826809
- VRT826809
- VX809
- Lumacaftor component of orkambi
- VRT-325
- VRT-422
- VRT-532
- VX 809
- VRT 826809
- EGP8L81APK
- CHEBI:90951
- ORKAMBI COMPONENT LUMACAFTOR
- lumacaftorum
- RefChem:154271
- DTXCID80162014
- VX-809 (Lumacaftor)
- MFCD16659051
- Lumacaftor [INN]
- Lumacaftor [USAN:INN]
- UNII-EGP8L81APK
- C24H18F2N2O5
- VX8
- LUMACAFTOR [MI]
- Lumacaftor (USAN/INN)
- Lumacaftor (VX-809)
- LUMACAFTOR [USAN]
- LUMACAFTOR [WHO-DD]
- Lumacaftor(vx-809vx809)
- MLS006011120
- SCHEMBL377028
- Lumacaftor(vx-809vx809)?
- GTPL7481
- orb1305285
- LUMACAFTOR [ORANGE BOOK]
- SCHEMBL29355737
- SCHEMBL29355738
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