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TELOTRISTAT
SynDRA canonical compound SYN0030055 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TPH1 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | diarrhea |
|---|
| Disease area | gastroenterology |
|---|
All known targets
Mechanisms of action (all sources)
- Serotonin release inhibitor
- Serotonin receptor antagonist
- TPH2 INHIBITOR
- Tryptophan 5-hydroxylase inhibitor
- TPH1 INHIBITOR
- tryptophan hydroxylase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PTGS2
- ADORA3
- SLC6A2
- PTGS1
- KCNH2
- NR1I2
- NPY1R
- MLNR
- MC3R
- MAOA
- ACHE
- OPRD1
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- NR3C1
- OPRM1
- OPRK1
- HRH3
- PDE3A
- PDE4A
- PDE4D
- PGR
- PPARG
- SCN5A
- SLC29A1
- SLC6A3
- SLC6A4
- HTR1A
- HRH2
- ADORA1
- CCKAR
- ADORA2A
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- GAMT
- GNMT
- HNMT
- KSYK
- NNMT
- NR1I3
- PNMT
- SYK
ATC classes
- A16A · OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Cross-references
Synonyms
- LP-778902
- LX-3033
- LP 778902
- telotristatum
- RefChem:57925
- DTXCID4068296
- A16AX15
- MFCD20528907
- Telotristat [USAN]
- Telotristat [USAN:INN]
- UNII-381V4FCV2Z
- Telotristat (Standard)
- TELOTRISTAT [MI]
- TELOTRISTAT [INN]
- Telotristat (USAN/INN)
- Telotristat, LP778902
- A1IT9
- TELOTRISTAT [WHO-DD]
- C25H22ClF3N6O3
- SCHEMBL612353
- orb1306323
- CHEBI:177736
- HY-13055BR
- AC90625A
- EX-A1620
- BDBM50145648
- HY-13055B
- AKOS027338710
- NCGC00485953-01
- AC-35764
- FT104238
- MS-30026
- D09973
- F86418
- T21506
- BRD-K63178091-001-01-1
- AKOS030527844
- DB-200547
Reported adverse events
- Depression
- Flatulence
- Headache
- Decreased appetite
- Nausea
- Pyrexia
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