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COBICISTAT
SynDRA canonical compound SYN0029961 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- CYP3A43
- CYP3A5
- CYP3A7
- ABCG2
- SLCO1B3
Mechanisms of action (all sources)
- Cytochrome P450 inhibitor
- CYP3A4 INHIBITOR
- Cytochrome P450 3A inhibitor
- CYP3A5 INHIBITOR
- CYP3A43 INHIBITOR
- CYP3A7 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP2D6
- CYP1A2
- CYP2C19
- CYP2C9
- NR1I2
Drug classes
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral Agents
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Metabolic Side Effects of Drugs and Substances
- Cytochrome P450 2D6 Inhibitors
- P-Glycoprotein Inhibitors
- Organic Anion Transporting Polypeptide 1B1 Inhibitors
- Organic Anion Transporting Polypeptide 1B3 Inhibitors
ATC classes
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
- DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- EVOTAZ
- GENVOYA
- PREZCOBIX
- PREZCOBIX PED
- STRIBILD
- SYMTUZA
- TYBOST
- Tybost
- GS 9350
- tybost
- Cobicistat on silicon dioxide
- Cobicistat, (r,r,s)-
- GS-9350
- Cobicistat component of evotaz
- Cobicistat component of genvoya
- Cobicistat component of prezcobix
- Cobicistat component of rezolsta
- Cobicistat component of stribild
- Cobicistat component of symtuza
- Cobicistat (GS-9350)
- UNII-LW2E03M5PG
- Cobicistat,GS-9350
- CHEBI:72291
- LW2E03M5PG
- 1,3-thiazol-5-ylmethyl
- COBICISTAT, (R,R,S)-
- Cobicistat [USAN]
- Cobicistat [USAN:INN]
- cobicistatum
- Tybost (TN)
- COBICISTAT [MI]
- COBICISTAT [INN]
- COBICISTAT [JAN]
- Cobicistat; GS-9350
- COBICISTAT [VANDF]
- COBICISTAT [WHO-DD]
- Cobicistat (JAN/USAN/INN)
Reported adverse events
- Lactic acidosis
- Fanconi syndrome
- Rash
- Headache
- Nausea
- Fatigue
- Hepatomegaly
- Jaundice
- Ocular icterus
- Flatulence
- Abnormal dreams
- Dizziness
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