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IVACAFTOR
SynDRA canonical compound SYN0028930 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CFTR |
|---|
| Mechanism of action | CFTR channel potentiator |
|---|
| Indication | cystic fibrosis |
|---|
| Disease area | pulmonary |
|---|
All known targets
Mechanisms of action (all sources)
- CFTR channel potentiator
- CFTR POSITIVE MODULATOR
- Cystic fibrosis transmembrane conductance regulator positive modulator
- CFTR ACTIVATOR
- CFTR POTENTIATOR
- CFTR MODULATOR
- Cystic fibrosis transmembrane conductance regulator activator
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRB3
- ADORA3
- SLC6A2
- KCNH2
- NEIL2
- NEIL1
- MLNR
- MC4R
- MC3R
- MAOA
- ADORA1
- NR3C1
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- NPY1R
- OGG1
- NTHL1
- HRH2
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SLC29A1
- SLC6A3
- SLC6A4
- SMUG1
- TBXA2R
- HRH3
- HRH1
- ADORA2A
- CHRM2
- ADRA1A
- ADRA2A
- ADRA2B
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- GPX4
- IFNB1
- IFNG
- KSYK
- NSD2
- SYK
Drug classes
- Chloride Channel Agonists
- Membrane Transport Modulators
- Chloride Channel Activation Potentiators
- Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
- P-Glycoprotein Inhibitors
- Cytochrome P450 2C9 Inhibitors
- Cytochrome P450 3A Inhibitors
ATC classes
- R07A · OTHER RESPIRATORY SYSTEM PRODUCTS
Cross-references
Synonyms
- KALYDECO
- Kalydeco
- ORKAMBI
- SYMDEKO (COPACKAGED)
- TRIKAFTA (COPACKAGED)
- kalydeco
- VX 770
- VX-770
- Ivacaftor component of orkambi
- Ivacaftor component of symkevi
- Ivacaftor component of trikafta
- Kalydeco (TN)
- 1Y740ILL1Z
- TRIKAFTA COMPONENT IVACAFTOR
- SYMKEVI COMPONENT IVACAFTOR
- ORKAMBI COMPONENT IVACAFTOR
- ivacaftorum
- CHEBI:66901
- RefChem:58494
- DTXCID00158772
- R07AX02
- Elexacaftor, Tezacaftor, and Ivacaftor
- Ivacaftor (VX-770)
- Ivacaftor-d18
- MFCD17171361
- s1144
- Ivacaftor (4-tertbutyl-d9) (Major)
- Ivacaftor [USAN]
- Ivacaftor [USAN:INN]
- UNII-1Y740ILL1Z
- VX7
- IVACAFTOR [INN]
- IVACAFTOR [MI]
- Ivacaftor (USAN/INN)
- IVACAFTOR [VANDF]
- IVACAFTOR [WHO-DD]
- MLS006011119
- SCHEMBL351373
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