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REGORAFENIB
SynDRA canonical compound SYN0028680 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | TEK |
|---|
| Mechanism of action | RET tyrosine kinase inhibitor |
|---|
| Indication | colorectal cancer | gastrointestinal stromal tumors (GIST) |
|---|
| Disease area | oncology |
|---|
All known targets
- KDR
- KIT
- BRAF
- RET
- MAPK11
- TEK
- ABL1
- RAF1
- PDGFRB
- FLT4
- DDR2
- FLT1
Mechanisms of action (all sources)
- KIT INHIBITOR
- RAF inhibitor
- FGFR inhibitor
- PDGFR inhibitor
- VEGFR inhibitor
- RET tyrosine kinase inhibitor
- ABL1 INHIBITOR
- Tyrosine-protein kinase ABL inhibitor
- RAF1 INHIBITOR
- Serine/threonine-protein kinase RAF inhibitor
- Stem cell growth factor receptor inhibitor
- FGFR1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1H4
- OPRM1
- SYK
- CHRM1
- TBXA2R
- ADORA3
- MAOA
- RARG
- HTR1A
- YES1
- SLC6A3
- DRD1
- ABCB11
- NUAK2
- NTRK2
- NR3C1
- PCYT1A
- PASK
- PAK4
- PAK2
- OLA1
- PAICS
- NTRK3
- PDE4A
- OPRD1
- OPA1
- PDE3A
- AAK1
- PDE4D
- PIP4K2C
- PPARA
- PLK4
- PLK1
- PKN3
- PKN2
- PKN1
- PKMYT1
- PIP4K2A
- PDXK
- PIM2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CP2C9
- FGFR3
- IFNB1
- IFNG
- KSYK
- NSD2
Drug classes
- Protein Kinase Inhibitors
- Kinase Inhibitor
- Cytochrome P450 2C9 Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- STIVARGA
- Stivarga
- regorafenib monohydrate
- regorafenib hydrate
- anhydrous regorafenib
- BAY 73-4506
- Regorafenib hydrate
- Regorafenib anhydrous
- Regorafenib monohydrate
- BAY-73-4506
- BAY-73-4506 MONOHYDRATE
- BAY-734506
- BAY-734506 MONOHYDRATE
- Regorafenibum
- BAY73-4506
- Regorafenib (BAY 73-4506)
- UNII-24T2A1DOYB
- 24T2A1DOYB
- CHEMBL1946170
- CHEBI:68647
- Stivarga (TN)
- BAY73-4506 hydrochloride
- Regorafenib [USAN:INN]
- Regorafenib-13C-d3
- REGORAFENIB ANHYDROUS
- BAY 734506
- Regorafenib (BAY73-4506,Fluoro-Sorafenib)
- Regorafenib [INN]
- Fluoro-Sorafenib
- REGORAFENIB [MI]
- Regorafenib (USAN/INN)
- REGORAFENIB [VANDF]
- REGORAFENIB [WHO-DD]
- MLS006010303
- Regorafenib crystalline form I
- SCHEMBL432230
- Regorafenib,BAY 73-4506
Reported adverse events
- Alopecia
- Dysphonia
- Headache
- Hypertension
- Infection
- Lymphopenia
- Muscle spasms
- Nausea
- Neutropenia
- Pain
- Proteinuria
- Rash
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