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KW-2449
SynDRA canonical compound SYN0028187 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | ABL1 | AURKA | AURKB | FGFR1 | FLT3 |
|---|
| Mechanism of action | Abl kinase inhibitor | Aurora kinase inhibitor | FLT3 inhibitor |
|---|
All known targets
- ABL1
- FLT3
- AURKA
- AURKB
- FGFR1
Mechanisms of action (all sources)
- AURKA INHIBITOR
- Serine/threonine-protein kinase Aurora-A inhibitor
- AURKB INHIBITOR
- Serine/threonine-protein kinase Aurora-B inhibitor
- FLT3 INHIBITOR
- Tyrosine-protein kinase receptor FLT3 inhibitor
- ABL1 INHIBITOR
- Tyrosine-protein kinase ABL inhibitor
- Abl kinase inhibitor
- aurora kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AAK1
- PDGFRB
- PIK3CB
- PIK3CA
- PIK3C2G
- PIK3C2B
- PI4KB
- PHKG2
- PHKG1
- PGRMC1
- PFKP
- PEBP1
- PDXK
- PDPK1
- PDGFRA
- NTRK2
- PAK6
- PAK5
- PAK4
- PAK3
- PAK2
- PAK1
- PAICS
- OXSR1
- OPA1
- OLA1
- NUAK2
- NUAK1
- PIK3CD
- PIK3CG
- PIM1
- PIM2
- PRKCE
- PRKCD
- PRKCB
- PRKCA
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACB
Cross-references
Synonyms
- Tumor antigen-specific mAb (cancer), Kyowa
- Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kirin
- Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kogyo
- KW2449
- UNII-2D9N67F58G
- KW 2449 [WHO-DD]
- Piperazine, 1-(4-((1E)-2-(1H-indazol-3-yl)ethenyl)benzoyl)-
- RefChem:151583
- FLT3/ABL/AURORA KINASE INHIBITOR KW-2449
- MFCD18385006
- 2D9N67F58G
- 1-[4-[(1E)-2-(1H-Indazol-3-yl)ethenyl]benzoyl]piperazine
- 3-{2-[4-(PIPERAZINE-1-CARBONYL)PHENYL]ETHENYL}-1H-INDAZOLE
- YYLKKYCXAOBSRM-JXMROGBWSA-N
- KW-2449 Hydrochloride?
- orb15754
- MLS006011271
- GTPL5691
- SCHEMBL1596894
- SCHEMBL29356539
- CHEBI:91441
- GLXC-05879
- EX-A2306
- BDBM50355496
- NSC759675
- NSC800778
- s2158
- AKOS027460993
- CCG-267833
- CS-0231
- NSC-759675
- NSC-800778
- SDCCGSBI-0654393.P001
- NCGC00346569-05
- NCGC00346569-07
- AC-28419
- AS-71712
- FI153964
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