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PROPACETAMOL
SynDRA canonical compound SYN0027898 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | PTGS1 | PTGS2 |
|---|
| Mechanism of action | cyclooxygenase inhibitor |
|---|
| Indication | fever | pain relief |
|---|
| Disease area | endocrinology | neurology/psychiatry |
|---|
All known targets
- PTGS1
- PTGS2
- FAAH
- TRPV1
- TRPV4
- CYP2E1
- SLC6A2
- SLC6A4
- NR1I3
- CA2
- CA1
- CA4
Mechanisms of action (all sources)
- cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- FAAH INHIBITOR
- Anandamide amidohydrolase inhibitor
- TRPV1 OPENER
- Vanilloid receptor opener
- TRPV4 INHIBITOR
- SLC6A2 INHIBITOR
- SLC6A4 INHIBITOR
- CNR1 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- ADORA2A
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- NR1I2
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- HRH2
- HRH1
- GHSR
- BDKRB2
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
- CCKAR
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Central Nervous System Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Antipyretics
ATC classes
- N02B · OTHER ANALGESICS AND ANTIPYRETICS
- OPIOIDS
Cross-references
Synonyms
- proparacetamol
- Propacetamolum
- 5CHW4JMR82
- DTXCID7031589
- 4-acetamidophenyl 2-(diethylamino)acetate
- RefChem:176249
- N02BE05
- N, N-diethylglycine 4'-hydroxyacetanilide ester
- Propacetamol [INN]
- (4-acetamidophenyl) 2-(diethylamino)acetate
- Glycine, N,N-diethyl-, 4-(acetylamino)phenyl ester
- Propacetamol (INN)
- Propacetamolum [Latin]
- EINECS 266-390-1
- Propacetamol [INN:BAN]
- UNII-5CHW4JMR82
- Propacetamol (Standard)
- PROPACETAMOL [MI]
- SCHEMBL26155
- PROPACETAMOL [WHO-DD]
- N,N-Diethylglycine, ester with 4'-hydroxyacetanilide
- CHEBI:135089
- QTGAJCQTLIRCFL-UHFFFAOYSA-N
- Tox21_113811
- 4-Acetamidophenyl N,N-diethylglycinate
- AKOS015890722
- HY-145453R
- NCGC00253689-01
- MS-23737
- CAS-66532-85-2
- HY-145453
- CS-0374746
- NS00010541
- D07294
- BRD-K54496168-003-01-2
- Pro-Dafalgan
- 4-Acetamidophenyl N,N-diethylaminoacetate monohydrochloride
- F324034
Reported adverse events
- Hepatotoxicity
- Acetaminophen
- NGS
- Death
- Addiction
- TEN
- Respiratory depression
- Depression
- Accident
- Caffeine
- Phosphate
- ECT
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