← SynDRA

NIROGACESTAT

SynDRA canonical compound SYN0026874 — structure-anchored drug synonym record

All known targets

• APH1A
• APH1B
• NCSTN
• PSENEN
• PSEN1
• PSEN2
• NT5C3A

Mechanisms of action (all sources)

• APH1A INHIBITOR
• gamma-secretase inhibitor
• PSENEN INHIBITOR
• APH1B INHIBITOR
• PSEN1 INHIBITOR
• NCSTN INHIBITOR
• PSEN2 INHIBITOR
• NT5C3A INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• GSAP
• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP3A7
• KSYK
• NSD2
• SYK

Drug classes

• Antineoplastic Agents
• Gamma Secretase Inhibitors and Modulators

ATC classes

• L01X · OTHER ANTINEOPLASTIC AGENTS

Cross-references

• PubChem CID: 46224413
• ChEMBL: CHEMBL1770916
• DrugBank: DB12005
• ChEBI: 229217
• KEGG: D10960
• RxNorm: 2670631
• PDB: O6U
• Wikipedia: Nirogacestat
• TTD: D00GPQ
• LINCS BRD: BRD-K61691541

Synonyms

• OGSIVEO
• Ogsiveo
• PF-03084014
• PF-3084014
• PF 3084014
• UNII-QZ62892OFJ
• PF-03084014 (PF-3084014)
• QZ62892OFJ
• Z-3181
• PF03084014
• Nirogacestat [USAN]
• Nirogacestat (USAN/INN)
• GTPL7746
• SCHEMBL13184754
• CHEMBL1770916
• EX-A855
• DTXSID60235679
• MolPort-039-193-852
• ZINC38217837
• s8018
• AKOS030526383
• SB16726
• DB12005
• CS-1689
• NCGC00378713-01
• nirogacestatum
• PF3084014
• RefChem:854203
• MFCD19980705
• PF-3084014;PF-03084014
• NIROGACESTAT [INN]
• NIROGACESTAT [WHO-DD]
• orb1300331
• SCHEMBL29388600
• C27H41F2N5O
• PF-3084014 (y-secratase)
• CHEBI:229217
• GLXC-02736
• GLXC-07668