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SELUMETINIB
SynDRA canonical compound SYN0025683 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | MAP2K1 |
|---|
| Mechanism of action | MEK inhibitor |
|---|
All known targets
- MAP2K1
- MAP2K2
- AAK1
- BMP2K
- CSNK2A2
- EGFR
- SMC1A
- SMC2
Mechanisms of action (all sources)
- MEK inhibitor
- MAP2K1 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
- MAP2K2 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
- MAP2K1 NEGATIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- YJ005
- SYK
- ABL1
- PDE4D
- PIK3C2B
- PI4KB
- PHKG2
- PHKG1
- PGRMC1
- PGR
- PFKP
- PEBP1
- PDXK
- PDPK1
- PDGFRB
- PDGFRA
- PDE3A
- PIK3CA
- PCYT1A
- PASK
- PAK6
- PAK5
- PAK4
- PAK3
- PAK2
- PAK1
- PAICS
- OXSR1
- OPRM1
- OPA1
- OLA1
- PIK3C2G
- PIK3CB
- NUAK1
- PIK3CD
- PRKCD
- PRKCB
- PRKCA
- PRKAR2A
- PRKAG2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP2C9
- CP2CJ
- CP3A4
- ESR1
- KSYK
- NTM1A
- NTMT1
Drug classes
- Kinase Inhibitor
- Mitogen-Activated Protein Kinase Kinase 1 Inhibitors
- Mitogen-Activated Protein Kinase Kinase 2 Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- KOSELUGO
- Koselugo
- selumetinib sulfate
- koselugo
- AZD6244
- ARRY-142886
- AZD-6244
- ARRAY142886
- ARRY-886
- AZD-6244 HYD-SULFATE
- AZD-6244 HYDROGEN SULFATE
- AZD6244 (SELUMETINIB)
- SELUMETINIB (AZD6244)
- Selumetinib sulfate
- AZD 6244
- ARRY142886
- 6UH91I579U
- AZD6244 (Selumetinib)
- AZD6244(Selumetinib)
- CHEBI:90227
- CHEMBL1614701
- MEK inhibitors
- Selumetinib (AZD6244)
- UNII-6UH91I579U
- ARRY 142886
- NSC741078
- NCGC00189073-01
- NCGC00189073-02
- CAS-606143-52-6
- Selumetinib [USAN:INN]
- selumetinibum
- 3EW
- SELUMETINIB [MI]
- SELUMETINIB [INN]
- Selumetinib (USAN/INN)
- SELUMETINIB [USAN]
- AZD6244 - Selumetinib
- SELUMETINIB [WHO-DD]
Reported adverse events
- Dermatitis
- Dry skin
- Nausea
- Paronychia
- Pyrexia
- Rash
- Stomatitis
- Vomiting
- Abdominal pain
- Constipation
- Epistaxis
- Fatigue
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