DEXAMETHASONE ACETATE

SynDRA canonical compound SYN0025505 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · OTC
Primary target(s)	NR3C1
Mechanism of action	Glucocorticoid receptor agonist
Indication	allergic rhinitis \| anemia \| dermatitis herpetiformis (DH) \| enteritis \| hypercalcemia \| lupus \| multiple sclerosis \| nephrotic syndrome \| osteoarthritis \| psoriasis \| psoriatic arthritis \| rheumatoid arthritis \| ulcerative colitis
Disease area	allergy \| dermatology \| endocrinology \| gastroenterology \| hematology \| neurology/psychiatry \| rheumatology

All known targets

NR3C1
ANXA1
CYP3A4
CYP3A5
NOS2
NR0B1
NR3C2
ESRRA
PTGS2
IL5
IL4
AR

Mechanisms of action (all sources)

NR3C1 AGONIST
ESRRA AGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

ANDR
CFTR
CP3A4
CP3A7
MDR1
MRP1
NSD2
PRGR

Drug classes

Corticosteroid Hormone Receptor Agonists
Corticosteroid
Anti-Inflammatory Agents
Antiemetics
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Central Nervous System Agents
Gastrointestinal Agents
Glucocorticoids
Hormones
Peripheral Nervous System Agents
Anti-Allergic Agents

ATC classes

A01A · STOMATOLOGICAL PREPARATIONS
R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
S02B · CORTICOSTEROIDS
D07A · CORTICOSTEROIDS, PLAIN
D10A · ANTI-ACNE PREPARATIONS FOR TOPICAL USE
S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
S01B · ANTIINFLAMMATORY AGENTS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION

Cross-references

PubChem CID: 236702
ChEMBL: CHEMBL1651
DrugBank: DB14649
ChEBI: CHEBI:4463
KEGG: D02174
RxNorm: 2378841
Wikipedia: Dexamethasone_acetate
LINCS BRD: BRD-K47635719

Synonyms

Reported adverse events

Exophthalmos
Bradycardia
Acne
Anaphylactoid reaction
Hypertension
Sodium retention
Fluid retention
Petechiae
Fungal infection
Peptic ulcer
Erythema
Increased appetite

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