← SynDRA

DOXOFYLLINE

SynDRA canonical compound SYN0025491 — structure-anchored drug synonym record

All known targets

• ADORA1
• PDE4A
• PDE4B
• PDE4C
• PDE4D

Mechanisms of action (all sources)

• Adenosine receptor antagonist

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• DRD2
• ACHE
• KMT2A
• MMP9
• MMP1
• MLNR
• MC5R
• MC4R
• MC3R
• MAPK3
• MAPK14
• MAPK1
• MAOA
• LCK
• KCNH2
• GHSR
• HTR6
• HTR3A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HRH3
• HRH2
• HRH1
• HMGCR
• NPY1R
• NPY2R
• NR1I2
• NR3C1
• TBXAS1
• TBXA2R
• TACR2
• TACR1
• SLC6A4
• SLC6A3
• SLC6A2
• SLC29A1
• SIGMAR1
• SAMHD1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• MBD2

Drug classes

• Anti-Asthmatic Agents
• Antitussive Agents
• Bronchodilator Agents
• Central Nervous System Agents
• Enzyme Inhibitors
• Peripheral Nervous System Agents
• Phosphodiesterase Inhibitors
• Respiratory System Agents

ATC classes

• R03D · OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

Cross-references

• PubChem CID: 50942
• ChEMBL: CHEMBL1527608
• DrugBank: DB09273
• ChEBI: CHEBI:94714
• KEGG: D03898
• PDB: 7UH
• Wikipedia: Doxofylline
• TTD: D07NCN
• LINCS BRD: BRD-K70507123

Synonyms

• ansimar
• dioxyfilline
• doxophylline
• Doxofilina
• Ansimar
• Dioxyfilline
• Doxophylline
• Synasma
• Ventax
• ABC-12/3
• NSC-759645
• Ansimar (TN)
• Doxofyllinum
• 7-(1,3-Dioxolan-2-ylmethyl)theophylline
• MPM23GMO7Z
• NSC 759645
• CHEBI:94714
• DTXCID002968
• TMDO
• doxofillina
• 2-(7'-theophyllinemethyl)1,3-dioxolane
• RefChem:590414
• R03DA11
• Maxivent
• 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
• MFCD00865218
• NCGC00159330-02
• 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-purine-2,6-dione
• 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-1H-purine-2,6-dione
• Doxofylline [USAN:INN]
• Doxofilina [INN-Spanish]
• Doxofyllinum [INN-Latin]
• CAS-69975-86-6
• SR-01000789760
• EINECS 274-239-6
• UNII-MPM23GMO7Z
• BRN 0561195
• 2-(7'-Theophyllinemethyl)-1,3-dioxolane