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CANRENONE
SynDRA canonical compound SYN0025341 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | NR3C2 |
|---|
| Mechanism of action | Mineralocorticoid receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- Mineralocorticoid receptor antagonist
- NR3C2 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- DRD1
- NR3C1
- ADORA1
- OPRD1
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MBNL1
- MC3R
- MLNR
- NPY1R
- NR1I2
- OPRK1
- HRH3
- OPRM1
- PDE3A
- PDE4D
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- TBXA2R
- HTR1A
- HRH2
- ADORA2A
- CCKBR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP19A
- CP2CJ
- CP3A7
- ESRRA
- GCR
- GLI3
- NF2L2
- PRGR
- RARA
- SIAE
- UBE2N
Drug classes
- Diuretics
- Hormone Antagonists
- Mineralocorticoid Receptor Antagonists
- Natriuretic Agents
ATC classes
- C03D · ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Cross-references
Synonyms
- aldadiene
- phanurane
- Canrenona
- Spironolactone metabolite m1
- NSC-261713
- SC-9376
- Spironolactone related compound a
- Aldadiene
- Phanurane
- (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
- 78O20X9J0U
- Canrenone (USAN)
- 17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone
- NSC 261713
- Luvion
- CANRENONE [USAN]
- Aldadiene (VAN)
- (1'S,2R,2'R,10'R,11'S,15'S)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-6',8'-diene-5,5'-dione
- (10R,13S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
- Canrenonum
- Canrenone [USAN:INN]
- Canrenonum [INN-Latin]
- Canrenona [INN-Spanish]
- (8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
- CAS-976-71-6
- SMR000539206
- 11614 R. P.
- EINECS 213-554-5
- BRN 0046602
- UNII-78O20X9J0U
- 11614 R.P
- 20-Spiroxa-4,6-diene-3,21-dione
- NCGC00095148-01
- MFCD00071735
- SC9376
- CANRENONE [INN]
- CANRENONE [MI]
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