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SUXIBUZONE
SynDRA canonical compound SYN0025246 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Mechanism of action | cyclooxygenase inhibitor |
|---|
| Indication | joint pain | muscle pain |
|---|
| Disease area | neurology/psychiatry | rheumatology |
|---|
All known targets
- PTGS1
- PTGS2
- TAS2R2
- PTGIS
- FPR1
- CYP2C9
- Ptgs2
- Ptgs1
- NAPRT
Mechanisms of action (all sources)
- cyclooxygenase inhibitor
- Prostanoid receptor antagonist
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- TAS2R2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- SAMHD1
- KDR
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PGR
- PTGS1
- SLC6A2
- HTR2B
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- SMAD3
- TARDBP
- TBXA2R
- KCNH2
- HTR1A
- ADORA3
- CYP2C19
- ADRA1A
- ADRA2A
- AR
- CBX1
- CHRM1
- CHRM2
- CYP1A2
- CYP2C9
- HRH3
- CYP2D6
- CYP3A4
- DRD1
- DRD3
- ESR1
- F2
- HDAC6
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP19A
- CP2CJ
- CP2D6
- NF2L2
- NR1I2
- PRGR
- RXRA
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Cross-references
Synonyms
- calibene
- danilon
- suxibutazone
- 4-Hydroxymethylbutazolidine hemisuccinate
- Suxibuzona
- NSC-757866
- Calibene
- Suxibuzonum
- Solurol
- Flogos
- 4-((4-Butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)-4-oxobutanoic acid
- AE 17
- 4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate
- 4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
- CHEBI:32173
- NSC 757866
- 86TDZ5WP2B
- 4-Butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester)
- Succinic acid, monoester with 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione
- NCGC00016799-01
- Aflogan
- Flamilon
- Alfide
- CAS-27470-51-5
- 3,5-Pyrazolidinedione, 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-, hydrogen succinate (ester)
- Suxibuzonum [INN-Latin]
- Suxibuzona [INN-Spanish]
- Butanedioic acid, mono((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl) ester
- Butanedioic acid, mono[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester
- 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]
- SR-01000841241
- EINECS 248-477-6
- UNII-86TDZ5WP2B
- BRN 0904563
- Suxibuzon
- Suxibuzone [INN:BAN:JAN]
- Prestwick_113
- Spectrum_000321
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