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METHAPYRILENE
SynDRA canonical compound SYN0025234 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
All known targets
- HRH1
- ADRA2A
- ADRA2B
- CHRM1
- CHRM2
- CHRM5
- CYP2D6
- HTR2A
- HTR2B
- HTR2C
- HTR6
- SLC6A2
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- ACHE
- MAPK14
- NPY1R
- NPSR1
- NFKB1
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK1
- NR3C1
- MAOA
- LCK
- KDR
- KDM4E
- HTR1A
- HRH3
- HRH2
- HMGCR
- HDAC6
- NPY2R
- OPRD1
- ADORA1
- OPRK1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SIGMAR1
- SAMHD1
- PTPRC
- PTGS2
- PTGS1
- PTAFR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ACM4
- CP1A2
- CP2D6
- HTT
- JUN
- NR1I2
Drug classes
- Anti-Allergic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Hypnotics and Sedatives
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- metapyrilene
- paradormalene
- pyrinistab
- pyrinistol
- thenylene
- thenylpyramine
- methapyrilene hydrochloride
- methapyrilene HCl
- Metapirileno
- A-3322
- Metapyrilene
- Pyrinistol
- Restryl
- Semikon
- Sleepwell
- Tenalin
- Thionylan
- Thenylpyramine
- Paradormalene
- Lullamin
- Pyrathyn
- Pyrinistab
- Thenylene
- Rest-on
- Histadryl
- Lulamin
- methypyrilene
- Pyrahistine
- Histase
- Thenylene base
- Tenalin base
- Metapirilene
- Methapyrilenum
- Histadyl
- Methapyrilene, (base)
- AH-42
- NCI-C55550
- N,N-Dimethyl-N'-pyrid-2-yl-N'-2-thenylethylenediamine
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