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PIRIBEDIL
SynDRA canonical compound SYN0025124 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | DRD3 |
|---|
| Mechanism of action | Dopamine receptor agonist |
|---|
| Indication | dizziness | Parkinson's Disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD3
- ADRA2A
- ADRA2C
- DRD4
- HTR1A
- HTR2B
- ADRA1A
- ADRA1B
- ADRA1D
- ADRA2B
Mechanisms of action (all sources)
- Dopamine receptor agonist
- HTR1A PARTIAL AGONIST
- HTR2B ANTAGONIST
- ADRA1A ANTAGONIST
- ADRA2A ANTAGONIST
- ADRA2C ANTAGONIST
- DRD2 PARTIAL AGONIST
- DRD3 PARTIAL AGONIST
- DRD4 ANTAGONIST
- DRD3 AGONIST
- HTR1A AGONIST
- DRD2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- PDE4D
- KAT2A
- KCNH2
- KDR
- LMNA
- MAOA
- MAPK1
- MC3R
- MLNR
- NFKB1
- NR1I2
- NR3C1
- OPRD1
- OPRM1
- PDE3A
- PGR
- HTR3A
- PIN1
- PMP22
- PPARG
- PTGS2
- RGS4
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TARDBP
- TBXA2R
- TDP1
- USP1
- IDH1
- HTR2C
- ADORA1
- CYP2C9
- ADORA2A
- ADORA3
- ADRB1
- ADRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT2B
- ADA1A
- ADA2C
- ALOX12
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- IF4H
- INS
- LOX12
- PABP1
- TADA2A
Drug classes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Agonists
- Neurotransmitter Agents
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- piribedil methanesulfonate
- piribedil maleate
- ET-495
- trivastal
- trivastan
- piribedil hydrochloride
- piribedil HCl
- EU-4200
- Trivastal
- Trivastal lp
- 2-(4-Piperonyl-1-piperazinyl)pyrimidine
- ET 495
- EU 4200
- 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
- Piribedilum
- DO22K1PRDJ
- DTXCID7025188
- Piribendyl
- 2-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)pyrimidine
- RefChem:174519
- Piribedil Mono hydrochloride
- Mono-hydrochloride, Piribedil
- N04BC08
- ET495
- EU4200
- Trivastan
- 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine
- MFCD00868264
- 1-(2-Pyrimidyl)-4-piperonylpiperazine
- Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-
- Piribedil (INN)
- 2-(4-(3,4-Methylenedioxybenzyl)piperazino)pyrimidine
- 1-(3,4-Methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine
- NCGC00015857-05
- 2-(4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine
- PIRIBEDIL [INN]
- CAS-3605-01-4
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