← SynDRA

MELEVODOPA

SynDRA canonical compound SYN0025007 — structure-anchored drug synonym record

All known targets

• DDC
• DRD3
• DRD1
• DRD2
• DRD4
• DRD5
• ADRB1
• DBH
• HTR1A
• HTR7
• SLC6A2
• SLC6A3

Mechanisms of action (all sources)

• dopamine precursor
• dopamine precursor, dopamine receptor agonist
• dopamine receptor agonist
• DRD3 AGONIST
• Dopamine D3 receptor agonist
• ADRB1 AGONIST
• Beta-1 adrenergic receptor agonist
• DRD1 FULL AGONIST
• DRD2 FULL AGONIST
• DRD3 FULL AGONIST
• DRD4 FULL AGONIST
• DRD5 FULL AGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• DRD1
• ACHE
• HTR2B
• KDM4C
• KDM4E
• KDR
• LMNA
• MAOA
• MAPT
• OPRM1
• PDE3A
• PDE4A
• PGR
• PIN1
• PMP22
• POLK
• PTGS1
• SLC6A2
• SLC6A3
• SLC6A4
• SMPD1
• SNCA
• TBXA2R
• TDP1
• THPO
• KCNH2
• HTR1A
• ADORA3
• HSD17B10
• ADRA1A
• ADRA2A
• AR
• ARSA
• ATXN2
• CHRM1
• CHRM2
• CYP1A2
• CYP2C19
• CYP2C9
• CYP2D6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• AHR
• ALR
• CP3A7
• DRD2

Drug classes

• Anti-Dyskinesia Agents
• Antiparkinson Agents
• Central Nervous System Agents
• Catecholamine
• Dopamine Agents
• Dopamine Agonists
• Neurotransmitter Agents
• Cardiotonic Agents
• Cardiovascular Agents
• Peripheral Nervous System Agents
• Protective Agents
• Sympathomimetics

ATC classes

• N04B · DOPAMINERGIC AGENTS
• C01C · CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES

Cross-references

• PubChem CID: 23497
• ChEMBL: CHEMBL1328898
• DrugBank: DB13313
• ChEBI: CHEBI:134880
• KEGG: D07304
• Wikipedia: Melevodopa
• TTD: D0U0OT

Synonyms

• L-dopa methyl ester
• levodopa methyl ester
• levomet
• Levomet
• CHF-1301
• Chf-1301
• Levomet (TN)
• L-dopa-methyester
• L-Dopa methyl ester
• Levodopa methyl ester
• methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
• M30686U4X4
• methyl L-dopa
• melevodopum
• RefChem:156332
• DTXCID5028407
• N04BA04
• Melevodopa [INN]
• (S)-Methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate
• 3-Hydroxy-L-tyrosine methyl ester
• L-Tyrosine, 3-hydroxy-, methyl ester
• (-)-3,4-Dihydroxy-L-phenylalanine, methyl ester
• Melevodopa (INN)
• L-3-(3,4-Dihydroxyphenyl)alanine methyl ester
• ALANINE, 3-(3,4-DIHYDROXYPHENYL)-, METHYL ESTER, L-
• BRN 3056415
• Methyl 3-hydroxy-L-tyrosinate
• UNII-M30686U4X4
• LDME
• Lopac-D-1507
• MELEVODOPA [WHO-DD]
• Lopac0_000356
• SCHEMBL34004
• 4-14-00-02494 (Beilstein Handbook Reference)
• (S)-Methyl2-amino-3-(3,4-dihydroxyphenyl)propanoate
• methyl (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
• SCHEMBL29350486
• CHEBI:134880

Reported adverse events

• Hypersensitivity
• Rash
• Angioedema
• Ataxia
• Gastrointestinal pain
• Dyskinesia
• Hallucination
• Vomiting
• Depression
• Constipation
• Orthostatic hypotension
• Asthenia