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MIFEPRISTONE
SynDRA canonical compound SYN0024851 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PGR |
|---|
| Mechanism of action | Glucocorticoid receptor antagonist |
|---|
| Indication | diabetes mellitus | hyperglycemia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- NR3C1
- PGR
- AR
- NR1I2
- ADRA2B
- FYN
- Pgr
- OPRM1
- OPRK1
- Nr3c1
- NR3C2
- MAPK14
Mechanisms of action (all sources)
- PGR ANTAGONIST
- NR3C1 ANTAGONIST
- NR3C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD1
- ABCB11
- CYP2C9
- ADORA3
- ESRRA
- MMP9
- MAPK3
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- ABCB1
- MAPK1
- MTOR
- NFE2L2
- NPSR1
- NPY1R
- NPY2R
- NR1H4
- MPHOSPH8
- MAOA
- PDE3A
- LMNA
- LCK
- KDR
- KDM4A
- KCNH2
- KAT2A
- HTT
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- OPRD1
- PDE4A
- HRH1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- MCL1
- SYK
- RARA
- PPCEL
- NTM1A
- NSD2
- NF2L2
- MLLT3
- MDR1
- KSYK
- ANDR
- IFNG
- GLI3
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP19A
- TP53
Drug classes
- Progestational Hormone Receptor Antagonists
- Progestin Antagonist
- Abortifacient Agents
- Abortifacient Agents, Steroidal
- Contraceptive Agents
- Contraceptive Agents, Female
- Contraceptive Agents, Hormonal
- Contraceptives, Oral, Synthetic
- Contraceptives, Postcoital, Synthetic
- Hormone Antagonists
- Luteolytic Agents
- Menstruation-Inducing Agents
ATC classes
- G03X · OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Cross-references
Synonyms
- KORLYM
- Korlym
- MIFEPREX
- Mifeprex
- mifegyne
- mifeprex
- mifestone
- Mifepristona
- NSC-759862
- RU-38486
- RU-486
- RU486
- Mifegyne
- Mifedren
- HRA-052015
- Mifepristone (Cushing's disease)
- ACTH modulator (Cushing's disease), HRA
- Adrenocorticotropic hormone modulator (Cushing's disease), HRA Pharma
- Mifepristone (Cushing's disease), HRA pharma
- RU 486
- Mifepriston
- Corlux
- C29H35NO2
- MLS000069785
- 320T6RNW1F
- VGX-410C
- CHEBI:50692
- VGX-410
- NSC 759862
- NCGC00025179-05
- SMR000058481
- Mifepristonum [Latin]
- Mifepristona [Spanish]
- C-1073
- Mifepristonum
- RU486 (tetramethyl-rhodamine conjugated)
- Mifepristone [USAN:INN:BAN]
Reported adverse events
- Infection
- Dizziness
- Headache
- Nausea
- Vomiting
- Adrenal insufficiency
- Angioedema
- Arthralgia
- Back pain
- Blood potassium decreased
- Constipation
- Dry mouth
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