← SynDRA

NARLAPREVIR

SynDRA canonical compound SYN0024588 — structure-anchored drug synonym record

Mechanisms of action (all sources)

• HCV inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• HDAC6

ATC classes

• J05A · DIRECT ACTING ANTIVIRALS

Cross-references

• PubChem CID: 11857239
• ChEMBL: CHEMBL1255891
• DrugBank: DB14760
• ChEBI: 173104
• KEGG: D09644
• Wikipedia: Narlaprevir
• LINCS BRD: BRD-K38287497

Synonyms

• SCH-900518
• SCH900518
• Arlansa
• (1R,2S,5S)-3-(N-(((1-((tert-butylsulfonyl)methyl)cyclohexyl)amino)carbonyl)-3-methyl-l- valyl)-N-((1s)-1-((cyclopropylamino)(oxo)acetyl)pentyl)-6,6-dimethyl-3- azabicyclo(3.1.0)hexane-2-carboxamide
• 2857LA2O07
• (1R,2S,5S)-N-((1S)-1-(2-(cyclopropylamino)-2-oxoacetyl)pentyl)-3-((2S)-2-(((1-(((1,1- dimethylethyl)sulfonyl)methyl)cyclohexyl)carbamoyl)amino)-3,3-dimethylbutanoyl)-6,6- dimethyl-3-azabicyclo(3.1.0)hexane-2-carboxamide
• 3-Azabicyclo(3.1.0)hexane-2-carboxamide, N-((1S)-1-(2-(cyclopropylamino)-2- oxoacetyl)pentyl)-3-((2s)-2-((((1-(((1,1-dimethylethyl)sulfonyl)methyl)cyclohexyl) amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-, (1R,2S,5S)-
• (1R,2S,5S)-3-[(2S)-2-[[1-(tert-butylsulfonylmethyl)cyclohexyl]carbamoylamino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1R,2S,5S)-3-[N-({1-[(tert-Butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• Narlaprevir [USAN]
• Narlaprevir [USAN:INN]
• narlaprevirum
• UNII-2857LA2O07
• NARLAPREVIR [INN]
• Narlaprevir (USAN/INN)
• NARLAPREVIR [WHO-DD]
• SCHEMBL583183
• CHEMBL1255891
• GTPL11572
• TQP0852
• CHEBI:173104
• DTXSID801025746
• EX-A5389
• BDBM50537558
• ZINC68151111
• CS-0445
• NCGC00378650-01
• HY-10300
• D09644
• A916277
• Q27254268
• (1R,2S,5S)-3-((S)-2-(3-(1-((tert-butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1R,2S,5S)-3-{(2S)-2-[({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)amino]-3,3-dimethylbutanoyl}-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1R,2S,5S)-N-[(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]-6,6-dimethyl-3-[3-methyl-N-({1-[(2-methylpropane-2-sulfonyl)methyl]cyclohexyl}carbamoyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1S,4S,5R)-3-[(2S)-2-[[1-(tert-butylsulfonylmethyl)cyclohexyl]carbamoylamino]-3,3-dimethyl-butanoyl]-N-[(1S)-1-[2-(cyclopropylamino)-2-oxo-acetyl]pentyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-4-carboxamide
• (3S)-N-CYCLOPROPYL-3-{[(1R,2S,5S)-3-[(2S)-3,3-DIMETHYL-2-[({1-[(2-METHYLPROPANE-2-SULFONYL)METHYL]CYCLOHEXYL}CARBAMOYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXAN-2-YL]FORMAMIDO}-2-OXOHEPTANAMIDE
• RefChem:927513
• DTXCID001510010