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TREPROSTINIL
SynDRA canonical compound SYN0024426 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGIR |
|---|
| Mechanism of action | Platelet aggregation inhibitor |
|---|
| Indication | pulmonary arterial hypertension (PAH) |
|---|
| Disease area | pulmonary |
|---|
All known targets
- PTGIR
- PTGDR
- PTGER2
- P2RY12
- PPARD
- PTGER1
- PTGER3
- PTGER4
Mechanisms of action (all sources)
- Prostanoid receptor agonist
- Platelet aggregation inhibitor
- PTGIR AGONIST
- Prostanoid IP receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- HRH2
- HTR1A
- HTR2A
- HTR2B
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- NR1I2
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PPARG
- PTGS2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- HRH3
- HRH1
- ADORA2A
- GHSR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
- BDKRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP3A7
- PD2R
- PE2R1
- PE2R2
- PE2R3
- PE2R4
Drug classes
- Prostacycline Vasodilator
- Antihypertensive Agents
- Cardiovascular Agents
ATC classes
- B01A · ANTITHROMBOTIC AGENTS
Cross-references
Synonyms
- ORENITRAM
- Orenitram
- REMODULIN
- Remodulin
- TYVASO
- TYVASO DPI
- Tyvaso
- YUTREPIA
- Yutrepia
- treprost
- uniprost
- treprostinil sodium
- 15AU81
- LRX-15
- UT-15
- treprostinil diolamine
- Tresprostinil
- Treprostinilo
- Rumodolin
- Uniprost
- 15-AU-81
- L-606
- L606
- Tyvaso dpi
- Treprostinilum
- Viveta
- Treprostinil sodium
- LRX 15
- U 62840
- Remodulin (TN)
- Treprostinil [USAN:INN]
- Treprostinil (USAN/INN)
- U-62,840
- 15 AU81
- MRE-269
- RUM6K67ESG
- treprostinil phosphate
Reported adverse events
- Headache
- Rash
- Infection
- Vasodilatation
- Infusion
- Pain
- Nausea
- Infusion site reaction
- Flushing
- Syncope
- Cough
- Hypertension
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