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OMIPALISIB
SynDRA canonical compound SYN0024404 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG |
|---|
| Mechanism of action | mTOR inhibitor | PI3K inhibitor |
|---|
All known targets
- MTOR
- PIK3CG
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3R1
- PIK3R2
- PIK3R3
- PIK3R5
Mechanisms of action (all sources)
- MTOR inhibitor
- Serine/threonine-protein kinase mTOR inhibitor
- PIK3R1 INHIBITOR
- PIK3CB INHIBITOR
- PIK3CG INHIBITOR
- PIK3CA INHIBITOR
- PIK3R2 INHIBITOR
- PIK3CD INHIBITOR
- PIK3R5 INHIBITOR
- PIK3R3 INHIBITOR
- PI3K inhibitor
- PIK3CG MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PIK3C3
- PIM1
- PRKDC
- PIP4K2C
- SYK
- IRAK3
- PDE4D
- AAK1
- PASK
- PEBP1
- PDXK
- PDGFRB
- PAK4
- PGRMC1
- PAK2
- PAICS
- OPA1
- OLA1
- OGG1
- NUAK2
- NTRK1
- PFKP
- PIK3C2G
- PHKG2
- PRKACA
- PRKCA
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACG
- PRKACB
- PRKAA1
- NQO2
- PLK4
- PLK1
- PKN2
- PKN1
- PKMYT1
- PIP4K2A
- NTHL1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- NSD2
- RPTOR
- RICTOR
- PNMT
- PIM3
- PIM2
- PIK3R1
- PARP1
- NNMT
- GAMT
- MLST8
- MITF
- MAPKAP1
- KSYK
- IFNG
- HNMT
- GNMT
- TFE3
Cross-references
Synonyms
- GSK-2126458
- GSK2126458
- GSK 2126458
- UNII-1X8F5A3NA0
- 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide
- 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide
- 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
- 1X8F5A3NA0
- Omipalisib (GSK2126458, GSK458)
- C25H17F2N5O3S
- Omipalisib [USAN:INN]
- GSK 212
- 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide
- Benzenesulfonamide, 2,4-difluoro-N-(2-methoxy-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)-
- 2,4-difluoro-N-{2-methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl}benzenesulfonamide
- GSK458
- 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
- OMIPALISIB [INN]
- Omipalisib (USAN/INN)
- OMIPALISIB [USAN]
- OMIPALISIB [WHO-DD]
- MLS006011258
- Omipalisib; GSK2126458
- SCHEMBL623194
- GTPL8974
- Omipalisib (GSK2126458)
- CHEMBL1236962
- CHEBI:95093
- DTXSID10148604
- EX-A003
- GSK-458
- 3l08
- HMS3656D09
- BCP02252
- BDBM50145416
- MFCD16038929
- NSC764092
- NSC800807
- s2658
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