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FORETINIB
SynDRA canonical compound SYN0024164 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | MET |
|---|
| Mechanism of action | VEGFR inhibitor |
|---|
All known targets
- KDR
- MET
- FLT1
- FLT4
- FLT3
- KIT
- TEK
- PDGFRA
- PDGFRB
- AXL
- MST1R
Mechanisms of action (all sources)
- VEGFR inhibitor
- FLT3 INHIBITOR
- Tyrosine-protein kinase receptor FLT3 inhibitor
- KIT INHIBITOR
- Stem cell growth factor receptor inhibitor
- MET INHIBITOR
- Hepatocyte growth factor receptor inhibitor
- PDGFRB INHIBITOR
- Platelet-derived growth factor receptor inhibitor
- PDGFRA INHIBITOR
- TEK INHIBITOR
- Tyrosine-protein kinase TIE-2 inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ERBB4
- FGR
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHB6
- ERBB2
- ERBB3
- MAPK13
- ROCK2
- MAPK12
- RIPK4
- RIPK3
- RIPK2
- RIPK1
- FER
- FES
- MAPK11
- FGFR1
- FGFR2
- FGFR3
- EPHA5
- EPHA4
- EPHA3
- MAPK8
- SRC
- CSNK2A2
- SMO
- SLK
- DAPK3
- SIK2
- SIK1
- DDR1
- DDR2
- MAPK9
- RPS6KB1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CP2C9
- CP3A7
- CRBN
- KSYK
- NSD2
- SLC34A2
- TP53
- VHL
Cross-references
Synonyms
- GSK-1363089
- Gsk1363089
- EXEL-2880
- GSK-089
- GSK-1363089G
- GSK089
- GSK1363089G
- XL-880
- XL880
- GSK 089
- GSK 1363089
- GSK1363089
- XL 880
- GSK1363089, GSK089, foretinib, EXEL-2880, XL880
- 88Z
- MET inhibitors
- EXEL 2880
- Foretinib (GSK1363089)
- Foretinib(XL880)
- 81FH7VK1C4
- GSK 1363089G
- N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
- n-(3-fluoro-4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
- N-(3-Fluoro-4-{[6-Methoxy-7-(3-Morpholin-4-Ylpropoxy)quinolin-4-Yl]oxy}phenyl)-N'-(4-Fluorophenyl)cyclopropane-1,1-Dicarboxamide
- N-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- N-(3-Fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl]oxy)phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin 4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- xl-880, Foretinib
- FORETINIB [INN]
- Foretinib (USAN/INN)
- Foretinib [USAN:INN]
- FORETINIB [USAN]
- FORETINIB [WHO-DD]
- UNII-81FH7VK1C4
- MLS006010302
- SCHEMBL371804
- Foretinib - GSK1363089
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