← SynDRA

R-1487

SynDRA canonical compound SYN0024152 — structure-anchored drug synonym record

All known targets

• MAPK14

Mechanisms of action (all sources)

• MAPK14 INHIBITOR
• MAP kinase p38 alpha inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• NLK
• GAK
• MAPK10
• MAPK11
• DDR1
• STK36
• MAPK8
• MAPK9
• RPS6KA3
• COQ8A
• RPS6KA4
• ABL1
• NTRK3
• NTRK1
• NTRK2
• PDPK1
• PAK1
• PAK4
• PBK
• PHKG2
• PIM1
• PIM2
• PIM3
• PKN2
• NEK4
• MET
• NEK2
• MKNK2
• MINK1
• MELK
• MATK
• MARK3
• MARK2
• MAPKAPK5
• MAPKAPK3
• MAPKAPK2
• MAPK13
• MAPK12
• MAPK1
• MAP4K5

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ALOX12
• GPX1
• KC1D
• KPCD2
• KPCD3
• LOX12
• M4K4
• MK01
• MK08
• MK09

Cross-references

• PubChem CID: 11406590
• ChEMBL: CHEMBL1230122
• DrugBank: DB06518
• ChEBI: 233225
• PDB: 3FN
• TTD: D04YHW

Synonyms

• 6-(2,4-difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
• UNII-IO0DCY55NQ
• IO0DCY55NQ
• CHEMBL1230122
• 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-Pyrido[2,3-d]pyrimidin-7(8H)-one
• 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2h-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8h)-one
• Kinome_3762
• SCHEMBL5120612
• KKKRKRMVJRHDMG-UHFFFAOYSA-N
• HMS3401C13
• BDBM50341342
• ZINC58633224
• AKOS027420928
• NCGC00262195-02
• KB-80224
• ACM449811921
• RefChem:178450
• R1487 cpd
• orb1299610
• SCHEMBL29527296
• ZSA81192
• EX-A14324
• NSC767348
• EBC-224062
• NSC-767348
• SDCCGRCH-0000039.P001
• NCGC00262195-03
• DB-070615
• CS-0003671
• T7667
• R1487?
• 3FN
• 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-D]pyrimidin-7(8H)-one
• C19H19ClF2N4O3
• R1487
• AC-35451
• R1487 (Hydrochloride)
• EX-A670
• 6-(2,4-Difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride