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DOLUTEGRAVIR
SynDRA canonical compound SYN0024125 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CYP3A4 | CYP3A5 | CYP3A7 | POU2F2 | SLC22A2 | UGT1A1 |
|---|
| Mechanism of action | HIV integrase inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- CYP3A5
- CYP3A7
- HIV IN
- POU2F2
- SIGMAR1
- SLC22A2
- Sigmar1
- Slc18a3
- TMEM97
- Tmem97
- UGT1A1
Mechanisms of action (all sources)
- HIV integrase INHIBITOR
- HIV IN MODULATOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- ABCC2
- UGT2B4
- UGT2B15
- UGT1A9
- UGT1A6
- UGT1A4
- UGT1A3
- SLCO1B3
- SLCO1B1
- SLC22A1
- NR1I2
- HDAC6
- CYP2D6
- CYP2C9
- CYP2C8
- CYP2C19
- CYP2B6
- CYP2A6
- CYP1A2
- ABCG2
- UGT2B7
Drug classes
- HIV Integrase Inhibitors
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral Agents
- Enzyme Inhibitors
- Integrase Inhibitors
- Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor
- Organic Cation Transporter 2 Inhibitors
- Multidrug and Toxin Extrusion Transporter 1 Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- DOVATO
- JULUCA
- TIVICAY
- TIVICAY PD
- TRIUMEQ
- TRIUMEQ PD
- Tivicay
- dolutegravir sodium
- tivicay
- GSK 1349572
- S-349572
- GSK-1349572
- GSK1349572
- GSK1349572A
- S/GSK1349572
- Dolutegravir (GSK1349572)
- UNII-DKO1W9H7M1
- CHEBI:76010
- DKO1W9H7M1
- Tivicay (TN)
- Dolutegravir Sodium (
- Dolutegravir DTG
- Dolutegravir [USAN]
- Dolutegravir (USAN)
- 1051375-16-6 (free)
- S-GSK1349572
- Dolutegravir [USAN:INN]
- Soltegravir
- HSDB 8152
- 3s3m
- 3s3n
- 3s3o
- DOLUTEGRAVIR [MI]
- DOLUTEGRAVIR [INN]
- DOLUTEGRAVIR [VANDF]
- SCHEMBL82071
- MLS006011137
- DOLUTEGRAVIR [WHO-DD]
Reported adverse events
- Arthralgia
- Headache
- Hypersensitivity
- Abdominal pain
- Abnormal dreams
- Depression
- Dizziness
- Fatigue
- Hepatitis
- Insomnia
- Nausea
- Pruritus
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