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SINEFUNGIN
SynDRA canonical compound SYN0023809 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | CARM1 |
|---|
| Mechanism of action | DNA methyltransferase inhibitor | RNA synthesis inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- DNMT inhibitor
- RNA synthesis inhibitor
- Stre-myc carB INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NNMT
- RNMT
- INMT
- PRMT1
- EHMT2
- PRMT5
- EHMT1
- SETD7
- TPMT
- TRDMT1
- SETD2
- NSD2
- PCMT1
- PCIF1
- NSUN6
- NSUN2
- NSD3
- ABL1
- NSD1
- AURKA
- MAPK1
- HDAC6
- GSK3B
- FGFR2
- DOT1L
- DNMT3A
- CSNK1D
- CDK2
- BRPF1
- BRD4
- TRIM24
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- GAMT
- GNMT
- HNMT
- IFNG
- METTL14
- METTL3
- PNMT
Drug classes
- Antifungal Agents
- Antimalarials
- Antiprotozoal Agents
Cross-references
Synonyms
- Sinefungine
- Sinefungina
- COMPOUND 57926
- LILLY 57926
- LY-57926
- ADENOSYL-ORNITHINE
- Sinefunginum
- Antibiotic A 9145
- Compound 57926
- Adenosylornithine
- A 9145
- Antibiotic 32232 RP
- Sinefungin [USAN:INN]
- Sinefungine [INN-French]
- Sinefunginum [INN-Latin]
- UNII-W2U467CIIL
- Sinefungina [INN-Spanish]
- 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid
- 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid
- BRN 3574678
- W2U467CIIL
- RP 32232
- LY 57926
- CHEBI:45453
- Decofuranuronic
- RefChem:886351
- DTXCID10130180
- C15H23N7O5
- SFG
- MFCD00057013
- 1aqj
- 1qaq
- 2h2j
- SINEFUNGIN [MI]
- SINEFUNGIN [INN]
- Sinefungin (USAN/INN)
- SINEFUNGIN [USAN]
- SINEFUNGIN [MART.]
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