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PERAMPANEL
SynDRA canonical compound SYN0023807 — structure-anchored drug synonym record
| Approval status | Approved · Rx |
|---|
| Primary target(s) | GRIA1 |
|---|
| Mechanism of action | Glutamate receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- Glutamate receptor antagonist
- GRIA4 ANTAGONIST
- GRIA3 ANTAGONIST
- GRIA2 ANTAGONIST
- GRIA1 ANTAGONIST
- GRIA1 INHIBITOR
- GRIA2 INHIBITOR
- GRIA3 INHIBITOR
- GRIA4 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- ADORA2A
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- NR1I2
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- HRH2
- HRH1
- HDAC6
- CACNA1C
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- AMPA Receptor Antagonists
- Cytochrome P450 3A4 Inhibitors
- Noncompetitive AMPA Glutamate Receptor Antagonist
- Cytochrome P450 2C8 Inhibitors
- UGT2B7 Inhibitors
- UGT1A9 Inhibitors
ATC classes
Cross-references
Synonyms
- FYCOMPA
- perampanel hydrate
- fycompa
- E2007
- E-2007
- ER-155055-90
- Fycompa
- E 2007
- Perampanel (USAN)
- 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'H)-one
- H821664NPK
- perampanelum
- CHEBI:71013
- RefChem:58336
- DTXCID50113992
- N03AX22
- Fycompa (TN)
- Perampanel [USAN:INN]
- UNII-H821664NPK
- 6ZP
- Perampanel(E2007
- Perampanel(E2007?
- PERAMPANEL [MI]
- PERAMPANEL [INN]
- Perampanel (JAN/USAN)
- PERAMPANEL [USAN]
- PERAMPANEL [VANDF]
- PERAMPANEL [WHO-DD]
- orb181081
- SCHEMBL194370
- GTPL7050
- PERAMPANEL [ORANGE BOOK]
- SCHEMBL29354621
- SCHEMBL29718723
- PRMWGUBFXWROHD-UHFFFAOYSA-N
- EX-A2128
- BDBM50184410
Reported adverse events
- Aggression
- Anger
- Anxiety
- Ataxia
- Back pain
- Confusional state
- Diplopia
- Dizziness
- Dysarthria
- Eosinophilia
- Fall
- Fatigue
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