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PITAVASTATIN
SynDRA canonical compound SYN0023604 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HMGCR |
|---|
| Mechanism of action | HMGCR inhibitor |
|---|
| Indication | hyperlipidemia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- HMGCR
- APOA1
- CYP2C8
- Hmgcr
- NR4A2
- RXRA
Mechanisms of action (all sources)
- HMGCR INHIBITOR
- HMG-CoA reductase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLCO1B1
- PDE4D
- ADORA1
- OPRM1
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NPY1R
- NR1I2
- NR3C1
- NR4A1
- OPRD1
- OPRK1
- PDE3A
- ADORA2A
- PGR
- PTGS2
- RARG
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B3
- SLCO2B1
- TBXA2R
- HTR3A
- HTR2C
- HTR2B
- CHRM1
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CASP3
- RGS4
- NTMT1
- NTM1A
- NSD2
- LRC26
- KSYK
- KCMB4
- KCMB2
- KCMB1
- GPX4
- GCR
- ESRRA
- CP3A4
- CP19A
- CASP7
- SYK
Drug classes
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- HMG-CoA Reductase Inhibitor
- Anticholesteremic Agents
- Antimetabolites
- Enzyme Inhibitors
- Hypolipidemic Agents
- Lipid Regulating Agents
ATC classes
- C10A · LIPID MODIFYING AGENTS, PLAIN
Cross-references
Synonyms
- LIVALO
- Livalo
- NIKITA
- Nikita
- PITAVASTATIN CALCIUM
- ZYPITAMAG
- Zypitamag
- nisvastatin
- itavastatin
- pitavastatin calcium hydrate
- pitavastatin calcium
- livalo
- Pitavastatine
- Pitavastatina
- NSC-760423
- Pitavastatin component of k-924 pivastatin
- Pitavastatin hemicalcium
- NK-104
- Nisvastatin
- UNII-IYD54XEG3W
- Flovas
- IYD54XEG3W
- 2C25H23FNO4Ca
- CHEBI:71258
- NK 104 (acid)
- AK-50694
- Itavastatin calcium
- Pitavastatin calcium (JAN)
- Alipza
- Livazo
- P 872441
- 6-Heptenoic acid,
- Itavastatin
- Pitavastatin [INN]
- Pitavastatin calcium
- CHEBI:32020
- M5681Q5F9P
- NSC 760423
Reported adverse events
- Constipation
- Hypersensitivity
- Myalgia
- Myopathy
- Pain in extremity
- Rhabdomyolysis
- Virologic failure
- Back pain
- Pain
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