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METHIXENE
SynDRA canonical compound SYN0023547 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | CHRM5 |
|---|
| Mechanism of action | Acetylcholine receptor antagonist |
|---|
| Indication | Parkinson's Disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
Mechanisms of action (all sources)
- Acetylcholine receptor antagonist
- CHRM1 ANTAGONIST
- Muscarinic acetylcholine receptor M1 antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- CHRM1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRA1A
- ADRA2A
- KCNH2
- CHRM2
- DRD1
- DRD3
- HTR1A
- SLC6A2
- ACHE
- PTGS1
- PDE3A
- PDE4A
- PGR
- SLC6A3
- SAMHD1
- MAOA
- SLC6A4
- TBXA2R
- TDP1
- OPRM1
- HTR2B
- KDR
- IDH1
- ADORA3
- HRH3
- HDAC6
- GMNN
- GLP1R
- F2
- ESR1
- ATXN2
- AR
- UBE2N
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- IL1B
- SYK
- SMAD3
- SMAD2
- RARA
- PPARG
- NSD2
- MDR1
- MDM4
- MDM2
- KSYK
- JUN
- IDHC
- ACM4
- GLI3
- ESR2
- CP3A7
- CP2D6
- CP2CJ
- CASP7
- CASP3
- BRCA1
- BARD1
- ADRB2
- ACM5
- TSHR
ATC classes
- N04A · ANTICHOLINERGIC AGENTS
Cross-references
Synonyms
- TREST
- metixene
- methixene hydrochloride monohydrate
- metixen
- tremaril
- tremonil
- metixene hydrochloride
- methixene hydrochloride
- metixene HCl
- methixene HCl
- Metixene
- Metixeno
- Atosil
- Contalyl
- Dalpan
- Methixart
- Methixen
- Methyloxan
- Metisene
- Metixenum
- Raunana
- Tremaril;Tremarit
- Tremonil
- Tremoquil
- Trest
- Methixen [German]
- Methixene hydrochloride
- Metisene [DCIT]
- Metixene hydrochloride
- Tremaril hydrochloride
- Metixene (INN)
- Metixene (TN)
- Metixene [INN:BAN]
- Metixeno [INN-Spanish]
- Metixenum [INN-Latin]
- Methixene (*hydrochloride*)
- Metixene (*hydrochloride*)
- Tremonil (*hydrochloride*)
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