METHYLPREDNISOLONE HEMISUCCINATE

SynDRA canonical compound SYN0023504 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Mechanism of action	glucocorticoid receptor agonist
Indication	hypercalcemia, thyroiditis, osteoarthritis, rheumatoid arthritis, seborrheic dermatitis, asthma, allergic rhinitis, shingles, conjunctivitis, ulcerative colitis, enteritis, anemia, multiple sclerosis, mycosis
Disease area	endocrinology, rheumatology, dermatology, pulmonary, allergy, infectious disease, ophthalmology, gastroenterology, hematology, neurology/psychiatry

All known targets

NR3C1
ANXA1
Ar
TRPC5

Mechanisms of action (all sources)

NR3C1 AGONIST
NR3C1 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

ANDR

Drug classes

Corticosteroid Hormone Receptor Agonists
Corticosteroid
Anti-Inflammatory Agents
Antiemetics
Central Nervous System Agents
Gastrointestinal Agents
Glucocorticoids
Hormones
Neuroprotective Agents
Peripheral Nervous System Agents
Protective Agents
Antineoplastic Agents

ATC classes

H02B · CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS
D07A · CORTICOSTEROIDS, PLAIN
D10A · ANTI-ACNE PREPARATIONS FOR TOPICAL USE
H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION

Cross-references

PubChem CID: 16923
ChEMBL: CHEMBL1201265
DrugBank: DB14644
ChEBI: CHEBI:135765
KEGG: D00751
RxNorm: 203856
Wikipedia: Methylprednisolone_succinate

Synonyms

A-METHAPRED
METHYLPREDNISOLONE
METHYLPREDNISOLONE SODIUM SUCCINATE
SOLU-MEDROL
Solu-Medrol
methylprednisolone succinate
methylprednisolone sodium succinate
Methylprednisolone succinate
Methylprednisolone Succinate
5GMR90S4KN
Methylprednisolone Hemisuccinate [USP]
Methylprednisolone hemisuccinate (USP)
6 alpha-Methylprednisolone Sodium Hemisuccinate
UrbasonSoluble
RefChem:389122
Succinate, Methylprednisolone
Hemisuccinate, Methylprednisolone
Sodium Succinate, Methylprednisolone
Sodium Hemisuccinate, Methylprednisolone
Methylprednisolone Hemisuccinate Monosodium Salt
Methylprednisolone hydrogen hemisuccinate
Methylprednisolone hydrogen succinate
Methylprednisolone succinate (Standard)
6a-Methylprednisolone 21-Hemisuccinate
NCGC00185763-01
EINECS 220-863-9
UNII-5GMR90S4KN
6alpha-Methylprednisolone 21-hemisuccinate
6-Methylprednisolone hemisuccinate
EC 220-863-9
SCHEMBL7915
Methylprednisolone Impurity 44
orb1305971
orb3025324
HY-B1900R
MSK8594
CHEBI:135765

Reported adverse events

Cardiac arrest
Exophthalmos
Fluid retention
Cushingoid
Headache
Sodium retention
Urticaria
Vertigo
Osteoporosis
Hypertension
Glaucoma
Tendon rupture

Look up METHYLPREDNISOLONE HEMISUCCINATE in the interactive SynDRA portal →