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DIPIVEFRIN
SynDRA canonical compound SYN0023501 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ADRA1A |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | glaucoma | intraocular pressure |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- ADRA1A
- ADRA2B
- ADRA2C
- ADRB1
- ADRA1B
- ADRA1D
- ADRA2A
- ADRB2
- ADRB3
- TADA2A
- PAH
- TNF
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA1A AGONIST
- ADRA2A AGONIST
- ADRB1 AGONIST
- ADRB2 AGONIST
- ADRA2C AGONIST
- ADRA1D AGONIST
- ADRA1B AGONIST
- ADRA2B AGONIST
- ADRB3 AGONIST
- TADA2A AGONIST
- ADRB1 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- GLP1R
- HDAC6
- POLI
- PTH1R
- SAMHD1
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic Agonists
- Adrenergic alpha-Agonists
- Adrenergic beta-Agonists
- alpha-Adrenergic Agonist
- beta-Adrenergic Agonist
- Catecholamine
- Adrenergic Agents
- Neurotransmitter Agents
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Cardiovascular Agents
- Mydriatics
ATC classes
- S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
- R03A · ADRENERGICS, INHALANTS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- B02B · VITAMIN K AND OTHER HEMOSTATICS
- A01A · STOMATOLOGICAL PREPARATIONS
- C01C · CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Cross-references
Synonyms
- AKPRO
- DIPIVEFRIN HYDROCHLORIDE
- PROPINE
- dipivefrine
- dipivefrin hydrochloride
- dipivefrin HCl
- Dipivefrine
- Dipivefrina
- Dipivalyl epinephrine
- DPE
- AKPro
- Dipivefrinum
- Propine
- Dipivefrin HCL
- Dipivefrin [USAN]
- K 30081
- Dipivefrin (USAN)
- Dipivefrina [INN-Spanish]
- Dipivefrine (INN)
- Dipivefrinum [INN-Latin]
- Ophtho-Dipivefrin
- Propine C Cap B.I.D.
- (+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate
- (-)-4-(1-Hydroxy-2-methylaminoethyl)-o-phenylendipivalat
- 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat
- 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate
- dipivalyl epinephrine
- 8Q1PVL543G
- CHEBI:4646
- 4-(1-hydroxy-2-(methylamino)ethyl)-o-phenylene divavalate
- Diopine
- Glaudrops
- dipivaloylepinephrine
- adrenaline dipivalate
- RefChem:589010
- DTXCID1028100
- S01EA02
- Dipivefrine [INN]
Reported adverse events
- Cardiac arrest
- Arrhythmia
- Clostridial infection
- Hypertension
- Nausea
- Bradycardia
- Headache
- Adverse reaction
- Hypotension
- Chondrolysis
- Infusion
- Epinephrine
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