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MIDODRINE
SynDRA canonical compound SYN0023470 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA1A |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | hypotension |
|---|
| Disease area | cardiology |
|---|
All known targets
- ADRA1A
- ADRA1B
- ADRA1D
- HSP90AA1
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA1A AGONIST
- Adrenergic receptor alpha-1 agonist
- ADRA1D AGONIST
- ADRA1B AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- HTR6
- NPY2R
- NPY1R
- MLNR
- MC4R
- MC3R
- MAOA
- KCNH2
- HTR7
- HTR5A
- NTSR1
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- NR3C1
- OPRD1
- GMNN
- SLC29A1
- TACR2
- TACR1
- SMAD3
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SAMHD1
- OPRK1
- PTGS2
- PTGS1
- PGR
- PDE6A
- PDE4D
- PDE4A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic alpha-Agonists
- alpha-Adrenergic Agonist
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-1 Receptor Agonists
- Cardiovascular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sympathomimetics
- Vasoconstrictor Agents
ATC classes
- C01C · CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Cross-references
Synonyms
- MIDODRINE HYDROCHLORIDE
- ORVATEN
- PROAMATINE
- midodrine monohydrochloride
- midodrin
- (+/-)-Midodrine
- midodrine hydrochloride
- midodrine HCl
- Midodrina
- ST-1085
- Alphamine
- Amatine
- Gutron
- Hipertan
- Metligene
- Midamine
- Midodrin
- Midodrinum
- ProAmatine
- Midodrine HCL
- Midodrine Monohydrochloride
- Midodrine hydrochloride [USAN]
- A-4020 Linz
- TS 701
- Midodrina [INN-Spanish]
- Midodrine (INN)
- Midodrine [BAN:INN]
- Midodrine [INN:BAN]
- Midodrine hydrochloride [USAN:JAN]
- Midodrinum [INN-Latin]
- Pro-Amatine
- Proamatine (TN)
- St. Peter 224
- Midodrine hydrochloride (JAN/USAN)
- Pro-Amatine (TN)
- DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
- (+-)-Midodrine hydrochloride
- (-)-Midodrin hydrochloride
Reported adverse events
- Dysuria
- Rash
- Chills
- Piloerection
- Pain
- Supine hypertension
- Pruritus
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