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LEVOBUPIVACAINE
SynDRA canonical compound SYN0023458 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | KCNA5 |
|---|
| Mechanism of action | voltage-gated potassium channel blocker |
|---|
| Indication | local anesthetic |
|---|
| Disease area | Anesthesia |
|---|
All known targets
- SCN4A
- KCNA5
- CYP2D6
- HTR3A
- KCND3
- KCNH2
- PTGER1
- SCN1A
Mechanisms of action (all sources)
- SCN4A BLOCKER
- Sodium channel protein type IV alpha subunit blocker
- voltage-gated potassium channel blocker
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ESR1
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KAT2A
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HRH2
- HRH1
- HMGCR
- FYN
- FLT1
- MMP9
- NPY1R
- NPY2R
- PTPRC
- TSHR
- TBXAS1
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SIGMAR1
- PTGS2
- NR3C1
- PTGS1
- PTAFR
- PRKCA
- PPP3CA
- PDE5A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Anesthetics
- Anesthetics, Local
- Central Nervous System Agents
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- N01B · ANESTHETICS, LOCAL
Cross-references
Synonyms
- CHIROCAINE
- chirocain
- levobupivacaine hydrochloride
- levobupivacaine HCl
- Levobupivacaina
- Bupivacaine (-)-form
- (-)-bupivacaine
- (s)-bupivacaine
- Bupivacaine, (-)-
- Bupivacaine, (s)-
- L-bupivacaine
- Novabupi
- Chirocaine (TN)
- Levobupivacaine (INN)
- Levobupivacaine [INN:BAN]
- Novabupi (TN)
- L(-)-Bupivacaine
- L-(-)-bupivacaine
- L-(-)-1-Butyl-2',6'-pipecoloxylidide
- (S)-1-Butyl-2',6'-pipecoloxylidide
- (S)-bupivacaine
- A5H73K9U3W
- CHEBI:6149
- 2',6'-Pipecoloxylidide, 1-butyl-, L-(-)-
- levobupivacainum
- Bupivacaine (-)-
- RefChem:153196
- DTXCID8028470
- N01BB10
- (S)-(-)-Bupivacaine
- MFCD00936851
- LEVOBUPIVACAINE [INN]
- Levobupivacaine free base
- NCGC00159482-02
- UNII-A5H73K9U3W
- Epitope ID:1597623
- SCHEMBL34537
- BIDD:GT0471
Reported adverse events
- Cardiac arrest
- ANA
- Bradycardia
- Restlessness
- Chondrolysis
- Hypertension
- Infusion
- Arachnoiditis
- Headache
- Hypoaesthesia
- Pyrexia
- Acne
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