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ISOCARBOXAZID
SynDRA canonical compound SYN0023443 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | MAOB |
|---|
| Mechanism of action | Monoamine oxidase inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
Mechanisms of action (all sources)
- Monoamine oxidase inhibitor
- MAOA INHIBITOR
- MAOB INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ADORA1
- HRH2
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- LMNA
- MC3R
- MC4R
- MLNR
- NEIL1
- NPY1R
- NR1I2
- NR3C1
- NTHL1
- OGG1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- TDP1
- HTR1A
- HRH1
- ADORA2A
- CHRM1
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Monoamine Oxidase Inhibitors
- Antidepressive Agents
- Central Nervous System Agents
- Enzyme Inhibitors
- Psychotropic Drugs
- Monoamine Oxidase Inhibitor
ATC classes
Cross-references
Synonyms
- MARPLAN
- Marplan
- marplan
- Ro 5-0831/1
- Ro 5-0831
- benazide
- isocarboxazide
- isocarboxyzid
- Isocarboxazide
- Isocarboxazida
- Enerzer
- NSC-169893
- RO-5-0831
- BMIH
- Benazide
- Isocarbonazid
- Isocarbossazide
- Isocarboxazidum
- Isocarboxyzid
- Maraplan
- Marplon
- Isocarbossazide [DCIT]
- Isocarboxazid (INN)
- Isocarboxazid [INN:BAN]
- Isocarboxazida [INN-Spanish]
- Isocarboxazide [INN-French]
- Isocarboxazidum [INN-Latin]
- Marplan (TN)
- Ro5-0831
- N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3
- 5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide
- isocarboxazid (usp-rs)
- NSC 169893
- NSC169893
- DTXCID003171
- 4-27-00-03999 (Beilstein Handbook Reference)
- Isocarboxacid
- RefChem:57807
Reported adverse events
- Suicide
- Anxiety
- Chills
- Constipation
- Dizziness
- Dry mouth
- Headache
- Insomnia
- Lethargy
- Nausea
- Orthostatic hypotension
- Palpitations
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