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MESTRANOL
SynDRA canonical compound SYN0023431 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ESR1 |
|---|
| Mechanism of action | Estrogen receptor agonist |
|---|
| Indication | contraceptive |
|---|
| Disease area | endocrinology |
|---|
All known targets
- ESR1
- Ar
- CNR1
- PGR
- SLC6A2
- SLC6A4
- CYP2C8
- ESR2
- NR1I2
- HTR4
- NR1I3
- OPRM1
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- NR1I2
- NR3C1
- DRD3
- ACHE
- KCNH2
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- HTR6
- KAT2A
- MLNR
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH2
- HRH1
- HMGCR
- HDAC6
- MC5R
- MMP9
- MMP1
- PTGS1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A3
- SLC29A1
- SIGMAR1
- PTPRC
- PTGS2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ANDR
- SYK
- PRGR
- NF2L2
- MLP3A
- KSYK
- JUN
- IP6K1
- GPR32
- GCR
- CP3A7
- CP3A4
- CP2CJ
- CP2C9
- CP1A2
- CFTR
- TSHR
Drug classes
- Estrogen Receptor Agonists
- Contraceptive Agents
- Contraceptive Agents, Female
- Contraceptive Agents, Hormonal
- Contraceptives, Oral, Hormonal
- Estrogens
- Hormones
- Reproductive Control Agents
- Estrogen
- estrogenic hormone
ATC classes
- L02A · HORMONES AND RELATED AGENTS
- G03C · ESTROGENS
- HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Cross-references
Synonyms
- ENOVID
- ENOVID-E
- ENOVID-E 21
- NORETHIN 1/50M-21
- NORETHIN 1/50M-28
- NORETHINDRONE AND MESTRANOL
- NORINYL
- NORINYL 1+50 21-DAY
- NORINYL 1+50 28-DAY
- NORINYL 1+80 21-DAY
- NORINYL 1+80 28-DAY
- ORTHO-NOVUM 1/50 21
- ethynylestradiol methyl ether
- inostral
- menophase
- norquen
- 3-Methoxyethynylestradiol
- 33355
- EE-3ME
- EE3-ME
- EE3ME
- EEI3ME
- NSC-84032
- Mestranol component of enovid
- Mestranol component of norinyl
- Mestranol component of ovulen
- Devocin
- Menophase
- Mestranolo
- Mestranolum
- Norquen
- Ovastol
- Component of Norinyl
- Component of Norquen
- Component of Ovulen
- Ethynylestradiol methyl ether
- Mestranol [Steroidal oestrogens]
- Mestranolo [DCIT]
Reported adverse events
- Cancer
- Breast cancer
- Dementia
- DVT
- TIA
- Cardiovascular disorder
- Nausea
- Headache
- Hirsutism
- Erythema nodosum
- Erythema multiforme
- Migraine
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