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MEGESTROL ACETATE
SynDRA canonical compound SYN0023423 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PGR |
|---|
| Mechanism of action | Progesterone receptor agonist |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- PGR
- NR3C1
- ABCB1
- Ar
- CYP2C9
Mechanisms of action (all sources)
- DNA inhibitor
- PGR AGONIST
- PGR BINDER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ESR2
- MAOA
- NPSR1
- NFE2L2
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPK3
- MAPK14
- MAPK1
- LMNA
- NPY2R
- LCK
- KDR
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- NPY1R
- OPRD1
- HMGCR
- SIGMAR1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP2C9
- CP2CJ
- CP3A7
- ESRRA
- GCR
- KSYK
- NF2L2
- NR1I2
- RARA
- SYK
Drug classes
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Contraceptive Agents
- Contraceptive Agents, Female
- Contraceptive Agents, Hormonal
- Contraceptives, Oral, Hormonal
- Contraceptives, Oral, Synthetic
- Reproductive Control Agents
- Progestin
- Appetite Stimulants
- Central Nervous System Agents
- Central Nervous System Stimulants
ATC classes
- L02A · HORMONES AND RELATED AGENTS
- G03D · PROGESTOGENS
- G03A · HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
- PROGESTOGENS AND ESTROGENS IN COMBINATION
Cross-references
Synonyms
- MEGACE
- MEGACE ES
- magestin
- megestryl acetate
- niagestin
- Megestrol
- Chronopil
- Megesterol acetate
- 5071
- BDH-1298
- NSC-71423
- SC-10363
- Megace
- Megace es
- Megestrolo
- Megestrolo [DCIT]
- Chronopil (TN)
- Megace (TN)
- Megestrol (INN)
- Megestrol [INN:BAN]
- Megestrolum [INN-Latin]
- 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
- megestrol-acetate
- megestrol acetate (ep monograph)
- medroxyprogesterone acetate impurity g
- TJ2M0FR8ES
- medroxyprogesterone acetate impurity g (ep impurity)
- megestrol acetate (usp monograph)
- megestrol acetate (usp-rs)
- Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
- MEGESTROL 17alpha-ACETATE
- Megestryl acetate
- Niagestin
- Megace ES
- Megeron
- Ovaban
Reported adverse events
- Asthenia
- Dyspepsia
- Flatulence
- Headache
- Hypertension
- Insomnia
- Nausea
- Pain
- Pneumonia
- Rash
- Vomiting
- Alopecia
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