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TRILOSTANE
SynDRA canonical compound SYN0023268 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ESR1 | ESR2 | HSD3B2 | JUN | NR3C1 |
|---|
| Mechanism of action | 3beta-hydroxy-delta5-steroid dehydrogenase inhibitor |
|---|
| Indication | Cushing's syndrome |
|---|
| Disease area | endocrinology |
|---|
All known targets
- HSD3B2
- ESR2
- ESR1
- JUN
- NR3C1
Mechanisms of action (all sources)
- HSD3B2 INHIBITOR
- 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II inhibitor
- 3beta-hydroxy-delta5-steroid dehydrogenase inhibitor
- ESR2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- ADORA2A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NPY1R
- NR1I2
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- HTR1A
- HRH3
- HRH2
- BDKRB2
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
- CCKAR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- ESRRA
- GCR
- GLI3
- HSPB1
- KSYK
- NF2L2
- NSD2
- RARA
- SYK
- TP53
Drug classes
- Abortifacient Agents
- Abortifacient Agents, Steroidal
- Antineoplastic Agents
- Enzyme Inhibitors
- Reproductive Control Agents
ATC classes
- H02C · ANTIADRENAL PREPARATIONS
Cross-references
Synonyms
- MODRASTANE
- Vetoryl
- modrastane
- modrefen
- modrenal
- desopan
- Trilostano
- Desopan
- NSC-758904
- WIN 24,540
- WIN-24540
- Modrastane
- Modrenal
- Trilocur
- Trilorale
- Desopan (TN)
- Modrenal (TN)
- Vetoryl (TN)
- Vetoryl, Trilostane
- Win-24540
- Trilostane (JAN/USAN)
- Win 24540
- NSC 758904
- L0FPV48Q5R
- Trilostanum
- CHEBI:32260
- DTXCID103706
- VETORYL CAPSULES
- RefChem:56170
- 4alpha,5-epoxy-17beta-hydroxy-3-oxoandrostane-2-carbonitrile
- 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one
- MFCD00199295
- CAS-13647-35-3
- Trilostanum [INN-Latin]
- Trilostano [INN-Spanish]
- UNII-L0FPV48Q5R
- KVJXBPDAXMEYOA-CXANFOAXSA-N
- Trilostane [USAN:INN:BAN:JAN]
Look up TRILOSTANE in the interactive SynDRA portal →