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HYDROCORTISONE VALERATE
SynDRA canonical compound SYN0023058 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C1 |
|---|
| Mechanism of action | glucocorticoid receptor agonist |
|---|
| Indication | corticosteroid-responsive dermatoses |
|---|
| Disease area | dermatology |
|---|
All known targets
- NR3C1
- ANXA1
- NOS2
- NR3C2
- ESRRA
- ESRRB
- ESRRG
- SERPINA6
- KCNA1
- SHBG
- SLC47A1
- FNTA
Mechanisms of action (all sources)
- Corticosteroid agonist
- NR3C1 AGONIST
- NR3C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ATAD5
- GMNN
- HDAC6
- HIF1A
- KMT2A
- NFE2L2
- POLI
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CFTR
- CP3A4
- IL1B
- NR1I2
- NSD2
- PRGR
- TLR3
Drug classes
- Corticosteroid Hormone Receptor Agonists
- Corticosteroid
- Anti-Inflammatory Agents
- Dermatologic Agents
ATC classes
- S01B · ANTIINFLAMMATORY AGENTS
- A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
- S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- D07A · CORTICOSTEROIDS, PLAIN
- D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
- A01A · STOMATOLOGICAL PREPARATIONS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- S02B · CORTICOSTEROIDS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Cross-references
Synonyms
- WESTCORT
- hydrocortisone pentanoate
- Hydrocortisone 17-valerate
- Cortisol 17-valerate
- NSC-759133
- Westcort
- NSC 759133
- hydrocortisone valerate (usp monograph)
- Hydrocortisone-17-valerate
- hydrocortisone valerate (usp-rs)
- DTXCID7025633
- CHEBI:50865
- RefChem:55354
- hydrocortisone valerate cream
- MLS000028655
- MLS001076102
- SMR000058860
- C26H38O6
- CAS-57524-89-7
- UNII-68717P8FUZ
- Hydrocortisone valerate [USAN]
- NCGC00018263-02
- Westcort (TN)
- EINECS 260-786-8
- Hydrocortisone valerate [USAN:USP]
- Opera_ID_1123
- SCHEMBL80603
- Hydrocortisone valerate (USP)
- orb1310767
- orb3139725
- MSK2250
- HMS2235G11
- HY-B1265
- Tox21_110853
- EBC-27120
- MFCD00083365
Reported adverse events
- Ototoxicity
- Cushingoid
- Sodium retention
- Hypertension
- Exophthalmos
- Tendon rupture
- Fluid retention
- Vertigo
- Perioral dermatitis
- Epidural lipomatosis
- Central serous chorioretinopathy
- Hypertrichosis
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