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PREDNICARBATE
SynDRA canonical compound SYN0022956 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C1 |
|---|
| Mechanism of action | Phospholipase activator |
|---|
| Indication | contact dermatitis | dermatitis | eczema | itching |
|---|
| Disease area | dermatology | Dermatology | neurology/psychiatry | ophthalmology |
|---|
All known targets
- NR3C1
- ESRRA
- ESRRB
- ESRRG
- PLA2G1B
- NR3C2
- SERPINA6
- HSD11B1
- ANXA1
- AR
- IL6
- GPBAR1
Mechanisms of action (all sources)
- Phospholipase activator
- NR3C1 AGONIST
- NR3C1 FULL AGONIST
- NR3C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- ADORA1
- OPRD1
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NFE2L2
- NPY1R
- NR1I2
- OPRK1
- ADORA2A
- OPRM1
- PDE3A
- PDE4D
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- HTR2A
- HTR1A
- HRH2
- HRH1
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Corticosteroid Hormone Receptor Agonists
- Corticosteroid
- Anti-Inflammatory Agents
- Glucocorticoids
- Hormones
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Alkylating Activity
- Alkylating Drug
- Alkylating Agents
- Antineoplastic Agents, Alkylating
- Noxae
ATC classes
- D07A · CORTICOSTEROIDS, PLAIN
- S02B · CORTICOSTEROIDS
- D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- A01A · STOMATOLOGICAL PREPARATIONS
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- L01A · ALKYLATING AGENTS
- A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
- H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- S01B · ANTIINFLAMMATORY AGENTS
- S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Cross-references
Synonyms
- DERMATOP
- DERMATOP E EMOLLIENT
- Dermatop
- prednitop
- Prednicarbato
- HOE-777
- LAS-189961
- LAS189961
- NSC-760042
- PREDNICARBATE COMPONENT OF LAS-41003
- S-77-0777
- S-770777
- Dermatop e emollient
- LAS-41003
- LAS-189962
- Antimicrobial (skin infections), Almirall
- Peitel
- Dermatop (TN)
- Hoe-777
- S-77 0777
- Prednicarbate (USP/INN)
- Hoe 777
- Dermatop E emollient
- Prednicarbatum
- V901LV1K7D
- S 770777
- NSC 760042
- DTXCID7025502
- LAS-41003 COMPONENT PREDNICARBATE
- RefChem:58047
- prednisolone-17-ethylcarbonate-21-propionate
- D07AC18
- MLS002154121
- Prednicarbatum [INN-Latin]
- UNII-V901LV1K7D
- Prednicarbat
- Prednicarbato [INN-Spanish]
Reported adverse events
- Cushingoid
- Exophthalmos
- Fluid retention
- Urticaria
- Hypertension
- Sodium retention
- Petechiae
- Headache
- Vertigo
- Glaucoma
- Infection
- Tendon rupture
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