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EXEMESTANE
SynDRA canonical compound SYN0022945 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP19A1 |
|---|
| Mechanism of action | Aromatase inhibitor |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
Mechanisms of action (all sources)
- CYP19A1 INHIBITOR
- Cytochrome P450 19A1 inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- HTR2A
- NR3C1
- OPRK1
- MAOA
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR1A
- MC4R
- HRH3
- HRH2
- HRH1
- GIPR
- GHSR
- GCGR
- ESR2
- MC3R
- ABCB11
- MLNR
- PTGS2
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- PGR
- EHMT2
- PDE4D
- PDE3A
- OPRM1
- OPRD1
- NTSR1
- NPY2R
- NPY1R
- EDNRB
- ADORA1
- CHRM1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP2CJ
- CP3A7
- ESRRA
- GLI3
- KSYK
- NF2L2
- NR1I2
- NSD2
- PRGR
- SYK
Drug classes
- Aromatase Inhibitors
- Aromatase Inhibitor
- Antineoplastic Agents
- Enzyme Inhibitors
- Estrogen Antagonists
- Hormone Antagonists
- Steroid Synthesis Inhibitors
ATC classes
- L02B · HORMONE ANTAGONISTS AND RELATED AGENTS
Cross-references
Synonyms
- AROMASIN
- Aromasin
- aromasine
- FCE 24304
- aromasin
- Exemestano
- FCE-24304
- FCE24304
- NSC-758907
- PNU-155971
- Aromasil
- Aromasine
- EXE
- Exemestance
- Exemestanum
- Nikidess
- Pfizer brand of exemestane
- Curator_000009
- Aromasin (TN)
- Aromasin, Exemestane
- Exemestano [INN-Spanish]
- Exemestanum [INN-Latin]
- Exemestane [USAN:INN:BAN]
- Exemestane (JAN/USP/INN)
- 6-Methylenandrosta-1,4-diene-3,17-dione
- 6-Methyleneandrosta-1,4-diene-3,17-dione
- 6-methylideneandrosta-1,4-diene-3,17-dione
- 6-Methylene-androsta-1,4-diene-3,17-dione
- Androsta-1,4-diene-3,17-dione, 6-methylene-
- PNU 155971
- NY22HMQ4BX
- Exemestane(FCE 24304)
- CHEBI:4953
- NSC713563
- NSC 758907
- SMR000466314
- CAS-107868-30-4
Reported adverse events
- Abdominal pain
- Depression
- Dizziness
- Fatigue
- Headache
- Insomnia
- Nausea
- Pain
- Vomiting
- Hot flush
- Alopecia
- Anxiety
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