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PALONOSETRON

SynDRA canonical compound SYN0022868 — structure-anchored drug synonym record

All known targets

• HTR3A
• HTR3B

Mechanisms of action (all sources)

• Serotonin receptor antagonist
• HTR3A ANTAGONIST
• Serotonin 3a (5-HT3a) receptor antagonist

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• KCNH2
• ADRA2C
• SLC6A4
• HRH1
• MUTYH
• NTHL1
• NR3C1
• NR1I2
• NPY1R
• NEIL1
• MLNR
• OPRK1
• MC4R
• MC3R
• MBD4
• MAOA
• OPRD1
• ADORA1
• KCND3
• PDE3A
• PDE4D
• PGR
• PTGS2
• SCN5A
• SLC29A1
• SLC6A2
• SLC6A3
• SMUG1
• TBXA2R
• TDG
• TDP1
• OPRM1
• HTR2C
• ADORA2A
• CHRM1
• ADORA3
• ADRA1A
• ADRA2A
• ADRA2B
• ADRB1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ESRRA

Drug classes

• Antiemetics
• Central Nervous System Agents
• Gastrointestinal Agents
• Neurotransmitter Agents
• Peripheral Nervous System Agents
• Serotonin 5-HT3 Receptor Antagonists
• Serotonin Agents
• Serotonin Antagonists
• Serotonin 3 Receptor Antagonists
• Serotonin-3 Receptor Antagonist

ATC classes

• A04A · ANTIEMETICS AND ANTINAUSEANTS

Cross-references

• PubChem CID: 6337614
• ChEMBL: CHEMBL1720
• DrugBank: DB00377
• ChEBI: CHEBI:85161
• KEGG: D07175
• RxNorm: 70561
• PDB: O7B
• Wikipedia: Palonosetron
• TTD: D04FVU
• LINCS BRD: BRD-K08924299

Synonyms

• AKYNZEO
• ALOXI
• PALONOSETRON HYDROCHLORIDE
• POSFREA
• Posfrea
• (-)-Palonosetron
• palonosetron hydrochloride
• aloxi
• RS 25259-197
• palonosetron HCl
• (-)-palonosetron
• Palonosetron, (3as, 3s)-
• NSC-743769
• Aloxi
• Onicit
• Palonosetron [INN]
• Aloxi (TN)
• RS-25233-197
• RS-25259-197
• 5D06587D6R
• NSC 743769
• 2-Qhbiqo
• Palonosetronum
• CHEBI:85161
• RS 25233 198
• RS 25259 198
• RS-25259
• RefChem:56726
• DTXCID6028317
• A04AA05
• RS25259
• RS25233197
• RS25233198
• RS25259197
• RS25259198
• RS 25233197
• RS 25233198
• RS 25259197

Reported adverse events

• Constipation
• Dyspepsia
• Headache
• Hypersensitivity
• Asthenia
• Erythema
• Fatigue