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RUCAPARIB
SynDRA canonical compound SYN0022765 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | PARP1 |
|---|
| Mechanism of action | PARP inhibitor |
|---|
All known targets
- PARP1
- PARP2
- PARP3
- PARP10
- PARP12
- PARP14
- PARP15
- PARP16
- PARP4
- TNKS
- TNKS2
Mechanisms of action (all sources)
- PARP inhibitor
- PARP1 INHIBITOR
- PARP 1, 2 and 3 inhibitor
- PARP3 INHIBITOR
- PARP2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE4D
- PIM3
- PARP9
- POLA1
- CDK16
- DYRK1A
- DYRK1B
- DYRK3
- ABL1
- PARP8
- PARP11
- PAK4
- PAK1
- OPRM1
- NR3C1
- NR1I2
- NPY1R
- NEK2
- MLNR
- MC4R
- MC3R
- MARK3
- MARK2
- MAPKAPK3
- MAPKAPK2
- MAPK13
- MAPK12
- MAPK1
- MAOA
- PDE3A
- PIM1
- PGR
- RPS6KB1
- TRIM24
- TIPARP
- TBXA2R
- STK3
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- CP2C9
- DYR1A
- GAMT
- GNMT
- GPX1
- GPX4
- HNMT
- KPCD2
- KSYK
- NNMT
- NSD2
- NTM1A
- NTMT1
- PNMT
- SYK
Drug classes
- Antineoplastic Agents
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-Ribose) Polymerase Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- RUBRACA
- Rubraca
- rucaparib camsylate
- AG-14447
- rucaparib phosphate
- AG-14699
- AG014699
- PF01367338
- PF-1367338-BW
- CO-338
- rubraca
- rucaparib camphorsulfonate
- UNII-8237F3U7EH
- 8237F3U7EH
- AK317822
- CHEBI:134689
- rucaparibum
- RefChem:57180
- DTXCID50105054
- L01XX55
- Rucaparib free base
- Rucaparib [INN]
- Kinome_3180
- Rucaparib [USAN:INN]
- RPB
- MFCD11977252
- RUCAPARIB [MI]
- Rucaparib (USAN/INN)
- RUCAPARIB [USAN]
- RUCAPARIB [WHO-DD]
- SCHEMBL844585
- Rucaparib(AG-014447)?
- GTPL7736
- orb1302838
- SCHEMBL29351768
- CHEBI:94311
- HMABYWSNWIZPAG-UHFFFAOYSA-N
- GLXC-04728
Reported adverse events
- Abdominal pain
- Dizziness
- Dysgeusia
- Fatigue
- Nausea
- Neutropenia
- Photosensitivity reaction
- Rash
- Stomatitis
- Thrombocytopenia
- Vomiting
- Decreased appetite
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