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FEBUXOSTAT
SynDRA canonical compound SYN0022558 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | XDH |
|---|
| Mechanism of action | Xanthine oxidase inhibitor |
|---|
| Indication | hyperuricemia |
|---|
| Disease area | nephrology |
|---|
All known targets
- XDH
- ABCG2
- BLVRB
- KCNH2
- Xdh
Mechanisms of action (all sources)
- Xanthine oxidase inhibitor
- XDH INHIBITOR
- Xanthine dehydrogenase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HDAC6
- TARBP2
- ABCC4
- SLC6A4
- SLC6A3
- SLC6A2
- SLC22A12
- PTGS1
- HRH3
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- HTR2B
- HTR1A
- PGR
- ABCB11
- F2
- ESR1
- DRD3
- DRD1
- CYP3A4
- CYP2D6
- CYP2C9
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- ADORA3
- ACHE
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- AHR
- ANDR
- ATAD5
- CP2C9
- ESRRA
- GLI3
- HDAC9
- HTT
- IP6K1
- NF2L2
- NR1I2
- RARA
Drug classes
- Xanthine Oxidase Inhibitors
- Antirheumatic Agents
- Gout Suppressants
- Xanthine Oxidase Inhibitor
ATC classes
- M04A · ANTIGOUT PREPARATIONS
Cross-references
Synonyms
- ULORIC
- Uloric
- februxostat
- feburic
- uloric
- adenuric
- NSC-758874
- TMX-67
- Adenuric
- Febuxostat krka
- Febuxostat mylan
- Febuxostat viatris (previously febuxostat mylan)
- TEI
- Febuxostat [USAN]
- S1547
- Tei-6720
- Uloric (TN)
- Febuxostat (JAN/USAN/INN)
- TMX-67, Adenuric, Uloric, Febuxostat
- 111GE013
- NSC 758874
- TMX 67
- Zurig
- Febuxostatum
- DTXCID1028576
- CHEBI:31596
- TEI6720
- RefChem:57913
- Febuxostat tablets 40 mg
- Febuxostat tablets 80 mg
- M04AA03
- Feburic
- MFCD00871598
- Febuxostat (Uloric)
- NCGC00182059-02
- SMR002529566
- CAS-144060-53-7
Reported adverse events
- Arthralgia
- Rash
- Death
- Infestation
- Nausea
- Guillain-Barre syndrome
- Stevens-Johnson syndrome
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