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ENZALUTAMIDE
SynDRA canonical compound SYN0022231 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | AR |
|---|
| Mechanism of action | Androgen receptor antagonist |
|---|
| Indication | prostate cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- AR
- Ar
- CYP2C19
- CYP2C8
- CYP3A4
- KLK3
- NR3C1
Mechanisms of action (all sources)
- AR ANTAGONIST
- AR MODULATOR
- AR INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- NR1I2
- ACHE
- NR3C2
- HRH2
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- OPRD1
- ADORA1
- OPRK1
- OPRM1
- PDE3A
- PDE4A
- PDE4D
- PTGS1
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- HRH1
- HDAC6
- GHSR
- GHR
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- GABRA1
- GABRA2
- GABRA3
- GABRA4
- GABRA5
- GABRA6
- GABRB1
- GABRB2
- GABRB3
- GABRD
- GABRE
- GABRG1
- GABRG2
- GABRG3
- GABRP
- GABRQ
Drug classes
- Androgen Receptor Antagonists
- Androgen Receptor Inhibitor
- Cytochrome P450 3A4 Inducers
- Cytochrome P450 2C9 Inducers
- Cytochrome P450 2C19 Inducers
ATC classes
- L02B · HORMONE ANTAGONISTS AND RELATED AGENTS
Cross-references
Synonyms
- XTANDI
- Xtandi
- xtandi
- MDV3100
- MDV-3100
- Enzalutamida
- Enzalutamide (AR inhibitor)
- MDV 3100
- Enzalutamide (MDV3100)
- MDV3100 (Enzalutamide)
- 93T0T9GKNU
- CHEBI:68534
- Enzalutamide [USAN]
- Enzalutamide [USAN:INN]
- UNII-93T0T9GKNU
- Xtandi (TN)
- ENZALUTAMIDE [MI]
- Enzalutamide; MDV3100
- Enzalutamide (JAN/USAN)
- ENZALUTAMIDE [INN]
- ENZALUTAMIDE [JAN]
- MDV3100, AldrichCPR
- ENZALUTAMIDE [VANDF]
- MLS006010067
- ENZALUTAMIDE [WHO-DD]
- SCHEMBL189749
- GTPL6812
- CHEMBL1082407
- DTXSID10912307
- EX-A046
- BCPP000169
- ENZALUTAMIDE [ORANGE BOOK]
- HMS3654L07
- HMS3672M13
- HMS3744C19
- NC-54
- AMY10296
Reported adverse events
- Breast tenderness
- Dysphagia
- Hypersensitivity
- Pain
- Seizure
- Anxiety
- Arthralgia
- Choking
- Constipation
- Dizziness
- Dysgeusia
- Epistaxis
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