← SynDRA

TRICLABENDAZOLE

SynDRA canonical compound SYN0022228 — structure-anchored drug synonym record

All known targets

• DNMT1
• TTR
• Trypano CYSP

Mechanisms of action (all sources)

• microtubule inhibitor
• Trypano CYSP INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• EHMT2
• NFE2L2
• TDP1
• TARDBP
• SNCA
• SMAD3
• RAPGEF4
• PTH1R
• NPSR1
• MAPT
• ERG
• IDH1
• HSP90AA1
• HDAC6
• GNAS
• GMNN
• GLP1R
• GLA
• USP1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ADA10
• ANDR
• ATG4B
• CP19A
• GEMI
• HDAC3
• HS90A
• IDHC
• KCMB1
• KCMB2
• KCNH2
• KCNK3
• KCNQ1
• PA21B

Drug classes

• Anthelmintic
• Anthelmintics
• Anti-Infective Agents
• Antiparasitic Agents
• Antiplatyhelmintic Agents
• Cytochrome P450 2D6 Inhibitors
• Cytochrome P450 1A2 Inhibitors
• Cytochrome P450 2B6 Inhibitors
• Cytochrome P450 2C19 Inhibitors
• Cytochrome P450 2C9 Inhibitors
• Cytochrome P450 2C8 Inhibitors
• Cytochrome P450 3A Inhibitors

ATC classes

• P02B · ANTITREMATODALS

Cross-references

• PubChem CID: 50248
• ChEMBL: CHEMBL1086440
• DrugBank: DB12245
• ChEBI: CHEBI:94759
• KEGG: D07364
• RxNorm: 2118525
• PDB: JA9
• Wikipedia: Triclabendazole
• TTD: D02VMJ
• LINCS BRD: BRD-K81916719

Synonyms

• EGATEN
• Egaten
• egaten
• fasinex
• Triclabendazol
• Fasinex
• EGA230B
• NSC-759250
• NVP-EGA230
• Egaten tm
• C14H9Cl3N2OS
• Triclabendazolum [INN-Latin]
• Triclabendazol [INN-Spanish]
• CCRIS 8988
• UNII-4784C8E03O
• CGA 89317
• CPD000466357
• MLS001424101
• CHEMBL1086440
• 4784C8E03O
• NCGC00164610-01
• Triclabendazole, 98%
• SMR000466357
• AK-68238
• Triclabendazolum
• NSC 759250
• CGA89317
• CGA-89317
• Fasinex (TN)
• Egaten (TN)
• TRICLABENDAZOLE [MI]
• Oprea1_236106
• Triclabendazole (USAN/INN)
• TRICLABENDAZOLE [INN]
• cid_50248
• MLS000759473
• MLS000876812

Reported adverse events

• Abdominal pain
• Abdominal pain upper
• Asthenia
• Chest discomfort
• Chest pain
• Cough
• Headache
• Hyperhidrosis
• Jaundice
• Nausea
• Pruritus
• Pyrexia