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MANIDIPINE 6300
SynDRA canonical compound SYN0022222 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | CACNA1C |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1C
- CACNA1D
- CACNA1F
- CACNA1S
- Trypano CYSP
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CACNA1D INHIBITOR
- CACNA1C INHIBITOR
- Trypano CYSP INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- OPRK1
- ESR1
- DRD3
- DRD2
- KCNH2
- NR1I2
- HRH1
- ADORA3
- PTGS2
- MAOA
- HTR1A
- HTR2A
- HTR2B
- TBXA2R
- HTR2C
- HTR3A
- SLC6A4
- SLC6A3
- MC3R
- PGR
- MLNR
- NPY1R
- SLC6A2
- HRH3
- OPRD1
- SLC29A1
- OPRM1
- PDE3A
- PDE4D
- NR3C1
- HDAC6
- HRH2
- ADORA1
- ADORA2A
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- GLI3
- SYK
- RARA
- PPARG
- NSD2
- NR1H4
- KSYK
- IFNG
- GCR
- ANDR
- ESRRA
- ESR2
- CP2D6
- CP2CJ
- CP2C9
- CP19A
- ATXN2
- TOR1A
Drug classes
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
- ACE INHIBITORS, COMBINATIONS
Cross-references
Synonyms
- manidipine
- manidipine dihydrochloride
- (+/-)-Manidipine
- franidipine
- manidipine hydrochloride
- manidipine HCl
- Manidipine
- Manidipino
- Artedil
- Franidipine
- MANIDIPINE
- 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Iperten
- Manidipine [INN]
- Manidipine (Manyper)
- C35H38N4O6
- CHEMBL312176
- Manidipine (INN)
- 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
- 2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin
- CV-4093
- Manidipine dihydrochloride
- Manidipine 2HCl
- Calslot
- Franidipine hydrochloride
- Manidipine.2HCl
- Manidipine (dihydrochloride)
- (+-)-Manidipine hydrochloride
- 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
- DSSTox_CID_796
- DSSTox_RID_75794
- DSSTox_GSID_20796
- 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-
- 6O4754US88
- manidipinum
- manidipine, (+-)-
- RefChem:809939
- DTXCID0023745
- C08CA11
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