← SynDRA
EPLERENONE
SynDRA canonical compound SYN0022001 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C2 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | congestive heart failure | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- NR3C2
- AR
- CYP3A5
- NR3C1
- Nr3c2
- PGR
Mechanisms of action (all sources)
- Cytochrome P450 inhibitor
- NR3C2 ANTAGONIST
- Mineralocorticoid receptor antagonist
- NR3C2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- ACHE
- MAOA
- KDR
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HDAC6
- GSK3B
- GIPR
- GHSR
- GCGR
- GALC
- MAPK1
- MC3R
- MC4R
- PDE4D
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- PTGS2
- PPARG
- PDE3A
- MLNR
- OPRM1
- OPRK1
- OPRD1
- NTSR1
- NR1I2
- NPY2R
- NPY1R
- FGFR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Aldosterone Antagonists
- Aldosterone Antagonist
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Hormone Antagonists
- Mineralocorticoid Receptor Antagonists
- Natriuretic Agents
ATC classes
- C03D · ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Cross-references
Synonyms
- INSPRA
- Inspra
- (+)-Eplerenone
- epoxymexrenone
- Eplerenona
- SC-66110
- SC-6611O
- Epoxymexrenone
- Selara
- CGP-30083
- Inspra (TN)
- Eplerenone (JAN/USAN/INN)
- Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
- CHEMBL1095097
- CHEBI:31547
- 6995V82D0B
- NCGC00159559-02
- Eplerenone [USAN]
- Epleremone
- CAS-107724-20-9
- HSDB 7522
- Eplerenone [USAN:INN:BAN]
- UNII-6995V82D0B
- Eplerenone- Bio-X
- SC 6110
- EPLERENONE [MI]
- EPLERENONE [INN]
- EPLERENONE [JAN]
- EPLERENONE [HSDB]
- EPLERENONE [VANDF]
- EPLERENONE [MART.]
- EPLERENONE [USP-RS]
- EPLERENONE [WHO-DD]
- SCHEMBL21515
- GTPL2876
- DTXSID2046094
- Eplerenone (JP17/USAN/INN)
Reported adverse events
- Hypertension
- Abdominal pain
- Cough
- Dizziness
- Fatigue
- Hepatic failure
- Influenza
- Proteinuria
- Albuminuria
Look up EPLERENONE in the interactive SynDRA portal →