NMS-1286937

SynDRA canonical compound SYN0021971 — structure-anchored drug synonym record

Clinical phase	Phase 2
Primary target(s)	FLT3 \| PLK1 \| PLK2 \| PLK3
Mechanism of action	PLK inhibitor

All known targets

FLT3
PLK1
PLK2
PLK3

Mechanisms of action (all sources)

PLK inhibitor

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

BMP2K
CCNA1
PIP4K2C
MYLK3
MELK
KIT
IMPDH2
FLT4
DYRK1A
CSNK2A2
CSNK1E
CSNK1D
CDK5R1
CDK5
CDK2
CDK1
CCNE1
CCNB1
CCNA2
RPS6KA4

Cross-references

PubChem CID: 24993189
ChEMBL: CHEMBL1094408
PDB: 071

Synonyms

SCHEMBL30495915
BDBM41575
US8614220, A85B1C1Z
DB-348927
8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-H]quinazoline-3-carboxamide

Look up NMS-1286937 in the interactive SynDRA portal →